Sarkar S - Search Results

1

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC. Williams A, et al. Among authors: sarkar s. Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79. Nat Chem Biol. 2008. PMID: 18391949 Free PMC article.

2

Congo red, doxycycline, and HSP70 overexpression reduce aggregate formation and cell death in cell models of oculopharyngeal muscular dystrophy.

Bao YP, Sarkar S, Uyama E, Rubinsztein DC. Bao YP, et al. Among authors: sarkar s. J Med Genet. 2004 Jan;41(1):47-51. doi: 10.1136/jmg.2003.014548. J Med Genet. 2004. PMID: 14729833 Free PMC article. No abstract available.

3

Lithium induces autophagy by inhibiting inositol monophosphatase.

Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC. Sarkar S, et al. J Cell Biol. 2005 Sep 26;170(7):1101-11. doi: 10.1083/jcb.200504035. J Cell Biol. 2005. PMID: 16186256 Free PMC article.

4

Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy.

Davies JE, Sarkar S, Rubinsztein DC. Davies JE, et al. Among authors: sarkar s. Hum Mol Genet. 2006 Jan 1;15(1):23-31. doi: 10.1093/hmg/ddi422. Epub 2005 Nov 25. Hum Mol Genet. 2006. PMID: 16311254

5

Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations.

Sarkar S, Rubinsztein DC. Sarkar S, et al. Autophagy. 2006 Apr-Jun;2(2):132-4. doi: 10.4161/auto.2387. Epub 2006 Apr 6. Autophagy. 2006. PMID: 16874097 Review.

6

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.

Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC. Williams A, et al. Among authors: sarkar s. Curr Top Dev Biol. 2006;76:89-101. doi: 10.1016/S0070-2153(06)76003-3. Curr Top Dev Biol. 2006. PMID: 17118264 Review.

7

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Sarkar S, et al. J Biol Chem. 2007 Feb 23;282(8):5641-52. doi: 10.1074/jbc.M609532200. Epub 2006 Dec 20. J Biol Chem. 2007. PMID: 17182613 Free article.

8

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8. doi: 10.1038/nchembio883. Epub 2007 May 7. Nat Chem Biol. 2007. PMID: 17486044 Free PMC article.

9

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages.

Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC. Floto RA, et al. Among authors: sarkar s. Autophagy. 2007 Nov-Dec;3(6):620-2. doi: 10.4161/auto.4898. Epub 2007 Aug 16. Autophagy. 2007. PMID: 17786022 Free article.

10

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC. Sarkar S, et al. Hum Mol Genet. 2008 Jan 15;17(2):170-8. doi: 10.1093/hmg/ddm294. Epub 2007 Oct 6. Hum Mol Genet. 2008. PMID: 17921520

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