Shaw DE - Search Results

1

Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth.

Doñate F, Parry GC, Shaked Y, Hensley H, Guan X, Beck I, Tel-Tsur Z, Plunkett ML, Manuia M, Shaw DE, Kerbel RS, Mazar AP. Doñate F, et al. Among authors: shaw de. Clin Cancer Res. 2008 Apr 1;14(7):2137-44. doi: 10.1158/1078-0432.CCR-07-4530. Clin Cancer Res. 2008. PMID: 18381955

2

Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224).

Doñate F, Juarez JC, Burnett ME, Manuia MM, Guan X, Shaw DE, Smith EL, Timucin C, Braunstein MJ, Batuman OA, Mazar AP. Doñate F, et al. Among authors: shaw de. Br J Cancer. 2008 Feb 26;98(4):776-83. doi: 10.1038/sj.bjc.6604226. Epub 2008 Feb 5. Br J Cancer. 2008. PMID: 18253124 Free PMC article.

3

Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities.

Doñate F, Juarez JC, Guan X, Shipulina NV, Plunkett ML, Tel-Tsur Z, Shaw DE, Morgan WT, Mazar AP. Doñate F, et al. Among authors: shaw de. Cancer Res. 2004 Aug 15;64(16):5812-7. doi: 10.1158/0008-5472.CAN-04-0440. Cancer Res. 2004. PMID: 15313924

4

Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1.

Juarez JC, Betancourt O Jr, Pirie-Shepherd SR, Guan X, Price ML, Shaw DE, Mazar AP, Doñate F. Juarez JC, et al. Among authors: shaw de. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. doi: 10.1158/1078-0432.CCR-06-0171. Clin Cancer Res. 2006. PMID: 16914587

5

Histidine-proline-rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain.

Juarez JC, Guan X, Shipulina NV, Plunkett ML, Parry GC, Shaw DE, Zhang JC, Rabbani SA, McCrae KR, Mazar AP, Morgan WT, Doñate F. Juarez JC, et al. Among authors: shaw de. Cancer Res. 2002 Sep 15;62(18):5344-50. Cancer Res. 2002. PMID: 12235005

6

Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours.

Cianfrocca ME, Kimmel KA, Gallo J, Cardoso T, Brown MM, Hudes G, Lewis N, Weiner L, Lam GN, Brown SC, Shaw DE, Mazar AP, Cohen RB. Cianfrocca ME, et al. Among authors: shaw de. Br J Cancer. 2006 Jun 5;94(11):1621-6. doi: 10.1038/sj.bjc.6603171. Br J Cancer. 2006. PMID: 16705310 Free PMC article. Clinical Trial.

7

Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells.

Guan X, Juarez JC, Qi X, Shipulina NV, Shaw DE, Morgan WT, McCrae KR, Mazar AP, Doñate F. Guan X, et al. Among authors: shaw de. Thromb Haemost. 2004 Aug;92(2):403-12. doi: 10.1160/TH04-02-0073. Thromb Haemost. 2004. PMID: 15269838

8

Extracellular tropomyosin: a novel common pathway target for anti-angiogenic therapy.

Doñate F, McCrae K, Shaw DE, Mazar AP. Doñate F, et al. Among authors: shaw de. Curr Cancer Drug Targets. 2004 Nov;4(7):543-53. doi: 10.2174/1568009043332781. Curr Cancer Drug Targets. 2004. PMID: 15578912 Review.

9

A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo.

Khalili P, Arakelian A, Chen G, Plunkett ML, Beck I, Parry GC, Doñate F, Shaw DE, Mazar AP, Rabbani SA. Khalili P, et al. Among authors: shaw de. Mol Cancer Ther. 2006 Sep;5(9):2271-80. doi: 10.1158/1535-7163.MCT-06-0100. Mol Cancer Ther. 2006. PMID: 16985061

10

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.

Juarez JC, Manuia M, Burnett ME, Betancourt O, Boivin B, Shaw DE, Tonks NK, Mazar AP, Doñate F. Juarez JC, et al. Among authors: shaw de. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7147-52. doi: 10.1073/pnas.0709451105. Epub 2008 May 14. Proc Natl Acad Sci U S A. 2008. PMID: 18480265 Free PMC article.

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