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The radical scavenger IAC (bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decantionate) decreases mortality, enhances cognitive functions in water maze and reduces amyloid plaque burden in hAβPP transgenic mice.
Puoliväli J, Nurmi A, Miettinen TK, Soleti A, Riccardino F, Kalesnykas G, Heikkinen T, Vartiainen N, Pussinen R, Tähtivaara L, Lehtimäki K, Yrjänheikki J, Canistro D, Sapone A, Spisni E, Paolini M. Puoliväli J, et al. Among authors: miettinen tk. J Alzheimers Dis. 2011;27(3):499-510. doi: 10.3233/JAD-2011-110881. J Alzheimers Dis. 2011. PMID: 21821875
beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits.
Malm T, Ort M, Tähtivaara L, Jukarainen N, Goldsteins G, Puoliväli J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen TK, Kanninen K, Leskinen S, Vartiainen N, Yrjänheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J, Koistinaho J. Malm T, et al. Among authors: miettinen tk. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8852-7. doi: 10.1073/pnas.0602896103. Epub 2006 May 24. Proc Natl Acad Sci U S A. 2006. PMID: 16723396 Free PMC article.