Hoffmann J - Search Results

1

Investigational developments for the treatment of progesterone-dependent diseases.

Möller C, Hoffmann J, Kirkland TA, Schwede W. Möller C, et al. Among authors: hoffmann j. Expert Opin Investig Drugs. 2008 Apr;17(4):469-79. doi: 10.1517/13543784.17.4.469. Expert Opin Investig Drugs. 2008. PMID: 18363513 Review.

2

Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist.

Fuhrmann U, Hess-Stumpp H, Cleve A, Neef G, Schwede W, Hoffmann J, Fritzemeier KH, Chwalisz K. Fuhrmann U, et al. Among authors: hoffmann j. J Med Chem. 2000 Dec 28;43(26):5010-6. doi: 10.1021/jm001000c. J Med Chem. 2000. PMID: 11150172

3

Subcellular distribution of epothilones in human tumor cells.

Lichtner RB, Rotgeri A, Bunte T, Buchmann B, Hoffmann J, Schwede W, Skuballa W, Klar U. Lichtner RB, et al. Among authors: hoffmann j. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11743-8. doi: 10.1073/pnas.171023398. Epub 2001 Sep 18. Proc Natl Acad Sci U S A. 2001. PMID: 11562452 Free PMC article.

4

Anti-tumor efficacy of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl) cytosine (4'-thio-FAC) in human pancreatic and ovarian tumor xenograft models.

Zajchowski DA, Biroc SL, Liu HL, Chesney SK, Hoffmann J, Bauman J, Kirkland T, Subramanyam B, Shen J, Ho E, Tseng JL, Dinter H. Zajchowski DA, et al. Among authors: hoffmann j. Int J Cancer. 2005 May 10;114(6):1002-9. doi: 10.1002/ijc.20835. Int J Cancer. 2005. PMID: 15645422

5

Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.

Klar U, Buchmann B, Schwede W, Skuballa W, Hoffmann J, Lichtner RB. Klar U, et al. Among authors: hoffmann j. Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7942-8. doi: 10.1002/anie.200602785. Angew Chem Int Ed Engl. 2006. PMID: 17006870 No abstract available.

6

Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone.

Hoffmann J, Vitale I, Buchmann B, Galluzzi L, Schwede W, Senovilla L, Skuballa W, Vivet S, Lichtner RB, Vicencio JM, Panaretakis T, Siemeister G, Lage H, Nanty L, Hammer S, Mittelstaedt K, Winsel S, Eschenbrenner J, Castedo M, Demarche C, Klar U, Kroemer G. Hoffmann J, et al. Cancer Res. 2008 Jul 1;68(13):5301-8. doi: 10.1158/0008-5472.CAN-08-0237. Cancer Res. 2008. PMID: 18593931

7

Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate.

Klar U, Hoffmann J, Giurescu M. Klar U, et al. Among authors: hoffmann j. Expert Opin Investig Drugs. 2008 Nov;17(11):1735-48. doi: 10.1517/13543784.17.11.1735. Expert Opin Investig Drugs. 2008. PMID: 18922109 Review.

8

In vitro characterization of ZK 230211--A type III progesterone receptor antagonist with enhanced antiproliferative properties.

Afhüppe W, Beekman JM, Otto C, Korr D, Hoffmann J, Fuhrmann U, Möller C. Afhüppe W, et al. Among authors: hoffmann j. J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):45-55. doi: 10.1016/j.jsbmb.2009.12.011. Epub 2010 Jan 4. J Steroid Biochem Mol Biol. 2010. PMID: 20043998

9

Steroid hormone receptors as targets for the therapy of breast and prostate cancer--recent advances, mechanisms of resistance, and new approaches.

Hoffmann J, Sommer A. Hoffmann J, et al. J Steroid Biochem Mol Biol. 2005 Feb;93(2-5):191-200. doi: 10.1016/j.jsbmb.2004.12.002. Epub 2005 Jan 28. J Steroid Biochem Mol Biol. 2005. PMID: 15860262

10

Studies on the development of resistance to the pure antiestrogen Faslodex in three human breast cancer cell lines.

Sommer A, Hoffmann J, Lichtner RB, Schneider MR, Parczyk K. Sommer A, et al. Among authors: hoffmann j. J Steroid Biochem Mol Biol. 2003 May;85(1):33-47. doi: 10.1016/s0960-0760(03)00139-0. J Steroid Biochem Mol Biol. 2003. PMID: 12798355

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