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L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase.
Blachier J, Cleret A, Guerin N, Gil C, Fanjat JM, Tavernier F, Vidault L, Gallix F, Rama N, Rossignol R, Piedrahita D, Andrivon A, Châlons-Cottavoz M, Aguera K, Gay F, Horand F, Laperrousaz B. Blachier J, et al. Among authors: gay f. Exp Cell Res. 2023 May 15;426(2):113568. doi: 10.1016/j.yexcr.2023.113568. Epub 2023 Mar 24. Exp Cell Res. 2023. PMID: 36967104
Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.
Vincent DF, Yan KP, Treilleux I, Gay F, Arfi V, Kaniewski B, Marie JC, Lepinasse F, Martel S, Goddard-Leon S, Iovanna JL, Dubus P, Garcia S, Puisieux A, Rimokh R, Bardeesy N, Scoazec JY, Losson R, Bartholin L. Vincent DF, et al. Among authors: gay f. PLoS Genet. 2009 Jul;5(7):e1000575. doi: 10.1371/journal.pgen.1000575. Epub 2009 Jul 24. PLoS Genet. 2009. PMID: 19629168 Free PMC article.
Asparagine Synthetase Expression and Phase I Study With L-Asparaginase Encapsulated in Red Blood Cells in Patients With Pancreatic Adenocarcinoma.
Bachet JB, Gay F, Maréchal R, Galais MP, Adenis A, MsC DS, Cros J, Demetter P, Svrcek M, Bardier-Dupas A, Emile JF, Hammel P, Ebenezer C, Berlier W, Godfrin Y, André T. Bachet JB, et al. Among authors: gay f. Pancreas. 2015 Oct;44(7):1141-7. doi: 10.1097/MPA.0000000000000394. Pancreas. 2015. PMID: 26355551 Clinical Trial.
524 results