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c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.
Velden JL, Alcorn JF, Guala AS, Badura EC, Janssen-Heininger YM. Velden JL, et al. Among authors: guala as. Am J Respir Cell Mol Biol. 2011 Apr;44(4):571-81. doi: 10.1165/rcmb.2009-0282OC. Epub 2010 Jun 25. Am J Respir Cell Mol Biol. 2011. PMID: 20581097 Free PMC article.
Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells.
Roberson EC, Tully JE, Guala AS, Reiss JN, Godburn KE, Pociask DA, Alcorn JF, Riches DW, Dienz O, Janssen-Heininger YM, Anathy V. Roberson EC, et al. Among authors: guala as. Am J Respir Cell Mol Biol. 2012 May;46(5):573-81. doi: 10.1165/rcmb.2010-0460OC. Epub 2011 Jul 28. Am J Respir Cell Mol Biol. 2012. PMID: 21799120 Free PMC article.
Induction of a mesenchymal expression program in lung epithelial cells by wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1).
van der Velden JL, Guala AS, Leggett SE, Sluimer J, Badura EC, Janssen-Heininger YM. van der Velden JL, et al. Among authors: guala as. Am J Respir Cell Mol Biol. 2012 Sep;47(3):306-14. doi: 10.1165/rcmb.2011-0297OC. Epub 2012 Mar 29. Am J Respir Cell Mol Biol. 2012. PMID: 22461429 Free PMC article.
Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation.
van der Velden JL, Hoffman SM, Alcorn JF, Tully JE, Chapman DG, Lahue KG, Guala AS, Lundblad LK, Aliyeva M, Daphtary N, Irvin CG, Janssen-Heininger YM. van der Velden JL, et al. Among authors: guala as. Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L866-75. doi: 10.1152/ajplung.00153.2013. Epub 2014 Mar 7. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24610935 Free PMC article.
Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation.
Reynaert NL, Ckless K, Korn SH, Vos N, Guala AS, Wouters EF, van der Vliet A, Janssen-Heininger YM. Reynaert NL, et al. Among authors: guala as. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8945-50. doi: 10.1073/pnas.0400588101. Epub 2004 Jun 7. Proc Natl Acad Sci U S A. 2004. PMID: 15184672 Free PMC article.
Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness.
Pantano C, Ather JL, Alcorn JF, Poynter ME, Brown AL, Guala AS, Beuschel SL, Allen GB, Whittaker LA, Bevelander M, Irvin CG, Janssen-Heininger YM. Pantano C, et al. Among authors: guala as. Am J Respir Crit Care Med. 2008 May 1;177(9):959-69. doi: 10.1164/rccm.200707-1096OC. Epub 2008 Feb 8. Am J Respir Crit Care Med. 2008. PMID: 18263801 Free PMC article.
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