Krudys KM - Search Results

1

Use of oral glucose minimal model-derived index of insulin sensitivity in subjects with early type 1 diabetes mellitus.

Krudys KM, Greenbaum CJ, Pihoker C, Vicini P. Krudys KM, et al. Metabolism. 2008 Apr;57(4):445-7. doi: 10.1016/j.metabol.2007.10.001. Metabolism. 2008. PMID: 18328342

2

Integrated model of hepatic and peripheral glucose regulation for estimation of endogenous glucose production during the hot IVGTT.

Krudys KM, Dodds MG, Nissen SM, Vicini P. Krudys KM, et al. Am J Physiol Endocrinol Metab. 2005 May;288(5):E1038-46. doi: 10.1152/ajpendo.00058.2004. Epub 2005 Jan 4. Am J Physiol Endocrinol Metab. 2005. PMID: 15632105 Free article.

3

Population approaches to estimate minimal model indexes of insulin sensitivity and glucose effectiveness using full and reduced sampling schedules.

Krudys KM, Kahn SE, Vicini P. Krudys KM, et al. Am J Physiol Endocrinol Metab. 2006 Oct;291(4):E716-23. doi: 10.1152/ajpendo.00346.2005. Am J Physiol Endocrinol Metab. 2006. PMID: 16954338 Free article.

4

Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice.

Hebert MF, Ma X, Naraharisetti SB, Krudys KM, Umans JG, Hankins GD, Caritis SN, Miodovnik M, Mattison DR, Unadkat JD, Kelly EJ, Blough D, Cobelli C, Ahmed MS, Snodgrass WR, Carr DB, Easterling TR, Vicini P; Obstetric-Fetal Pharmacology Research Unit Network. Hebert MF, et al. Among authors: krudys km. Clin Pharmacol Ther. 2009 Jun;85(6):607-14. doi: 10.1038/clpt.2009.5. Epub 2009 Mar 18. Clin Pharmacol Ther. 2009. PMID: 19295505 Free PMC article. Clinical Trial.

5

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.

Kharasch ED, Whittington D, Hoffer C, Krudys K, Craig K, Vicini P, Sheffels P, Lalovic B. Kharasch ED, et al. Clin Pharmacokinet. 2005;44(7):731-51. doi: 10.2165/00003088-200544070-00005. Clin Pharmacokinet. 2005. PMID: 15966756 Clinical Trial.

6

Efficacy of pulmonary insulin delivery in diabetic rats: use of a model-based approach in the evaluation of insulin powder formulations.

Amidi M, Krudys KM, Snel CJ, Crommelin DJ, Della Pasqua OE, Hennink WE, Jiskoot W. Amidi M, et al. Among authors: krudys km. J Control Release. 2008 May 8;127(3):257-66. doi: 10.1016/j.jconrel.2008.01.019. Epub 2008 Feb 12. J Control Release. 2008. PMID: 18353483

7

Assessing the probability of drug-induced QTc-interval prolongation during clinical drug development.

Chain AS, Krudys KM, Danhof M, Della Pasqua O. Chain AS, et al. Among authors: krudys km. Clin Pharmacol Ther. 2011 Dec;90(6):867-75. doi: 10.1038/clpt.2011.202. Epub 2011 Nov 2. Clin Pharmacol Ther. 2011. PMID: 22048226

8

Results from the IQ-CSRC prospective study support replacement of the thorough QT study by QT assessment in the early clinical phase.

Darpo B, Benson C, Dota C, Ferber G, Garnett C, Green CL, Jarugula V, Johannesen L, Keirns J, Krudys K, Liu J, Ortemann-Renon C, Riley S, Sarapa N, Smith B, Stoltz RR, Zhou M, Stockbridge N. Darpo B, et al. Clin Pharmacol Ther. 2015 Apr;97(4):326-35. doi: 10.1002/cpt.60. Clin Pharmacol Ther. 2015. PMID: 25670536 Clinical Trial.

9

Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development.

Mulugeta Y, Barrett JS, Nelson R, Eshete AT, Mushtaq A, Yao L, Glasgow N, Mulberg AE, Gonzalez D, Green D, Florian J, Krudys K, Seo S, Kim I, Chilukuri D, Burckart GJ. Mulugeta Y, et al. J Clin Pharmacol. 2016 Nov;56(11):1326-1334. doi: 10.1002/jcph.744. J Clin Pharmacol. 2016. PMID: 27040726 Free PMC article. Review.

10

Extrapolation of Adult Efficacy to Pediatric Patients With Chemotherapy-Induced Nausea and Vomiting.

Momper JD, Heinrichs MT, Krudys K, Griebel D, Kumar S, Kim I, Mehrotra N, Mulberg AE, Garimella N, Nelson R, Reaman G, Sinha V, Yao L, Zineh I, Burckart G, Sachs H, Mulugeta Y. Momper JD, et al. J Clin Pharmacol. 2020 Jun;60(6):775-784. doi: 10.1002/jcph.1577. Epub 2020 Jan 22. J Clin Pharmacol. 2020. PMID: 31967340

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