Tanaka T - Search Results

1

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).

Asano Y, Kitamura S, Ohra T, Itoh F, Kajino M, Tamura T, Kaneko M, Ikeda S, Igata H, Kawamoto T, Sogabe S, Matsumoto S, Tanaka T, Yamaguchi M, Kimura H, Fukumoto S. Asano Y, et al. Among authors: tanaka t. Bioorg Med Chem. 2008 Apr 15;16(8):4699-714. doi: 10.1016/j.bmc.2008.02.028. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18313930

2

Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKbeta inhibitors.

Sugiyama H, Yoshida M, Mori K, Kawamoto T, Sogabe S, Takagi T, Oki H, Tanaka T, Kimura H, Ikeura Y. Sugiyama H, et al. Among authors: tanaka t. Chem Pharm Bull (Tokyo). 2007 Apr;55(4):613-24. doi: 10.1248/cpb.55.613. Chem Pharm Bull (Tokyo). 2007. PMID: 17409557 Free article.

3

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).

Asano Y, Kitamura S, Ohra T, Aso K, Igata H, Tamura T, Kawamoto T, Tanaka T, Sogabe S, Matsumoto S, Yamaguchi M, Kimura H, Itoh F. Asano Y, et al. Among authors: tanaka t. Bioorg Med Chem. 2008 Apr 15;16(8):4715-32. doi: 10.1016/j.bmc.2008.02.027. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18313304

4

Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.

Saitoh M, Kunitomo J, Kimura E, Hayase Y, Kobayashi H, Uchiyama N, Kawamoto T, Tanaka T, Mol CD, Dougan DR, Textor GS, Snell GP, Itoh F. Saitoh M, et al. Among authors: tanaka t. Bioorg Med Chem. 2009 Mar 1;17(5):2017-29. doi: 10.1016/j.bmc.2009.01.019. Epub 2009 Jan 15. Bioorg Med Chem. 2009. PMID: 19200745

5

Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.

Hasui T, Matsunaga N, Ora T, Ohyabu N, Nishigaki N, Imura Y, Igata Y, Matsui H, Motoyaji T, Tanaka T, Habuka N, Sogabe S, Ono M, Siedem CS, Tang TP, Gauthier C, De Meese LA, Boyd SA, Fukumoto S. Hasui T, et al. Among authors: tanaka t. J Med Chem. 2011 Dec 22;54(24):8616-31. doi: 10.1021/jm2011645. Epub 2011 Nov 29. J Med Chem. 2011. PMID: 22074142

6

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.

Kawakita Y, Seto M, Ohashi T, Tamura T, Yusa T, Miki H, Iwata H, Kamiguchi H, Tanaka T, Sogabe S, Ohta Y, Ishikawa T. Kawakita Y, et al. Among authors: tanaka t. Bioorg Med Chem. 2013 Apr 15;21(8):2250-2261. doi: 10.1016/j.bmc.2013.02.014. Epub 2013 Feb 22. Bioorg Med Chem. 2013. PMID: 23490150

7

C17,20-lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors.

Matsunaga N, Kaku T, Itoh F, Tanaka T, Hara T, Miki H, Iwasaki M, Aono T, Yamaoka M, Kusaka M, Tasaka A. Matsunaga N, et al. Among authors: tanaka t. Bioorg Med Chem. 2004 May 1;12(9):2251-73. doi: 10.1016/j.bmc.2004.02.007. Bioorg Med Chem. 2004. PMID: 15080924

8

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

Miwatashi S, Arikawa Y, Kotani E, Miyamoto M, Naruo K, Kimura H, Tanaka T, Asahi S, Ohkawa S. Miwatashi S, et al. Among authors: tanaka t. J Med Chem. 2005 Sep 22;48(19):5966-79. doi: 10.1021/jm050165o. J Med Chem. 2005. PMID: 16162000

9

Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors.

Imaeda Y, Miyawaki T, Sakamoto H, Itoh F, Konishi N, Hiroe K, Kawamura M, Tanaka T, Kubo K. Imaeda Y, et al. Among authors: tanaka t. Bioorg Med Chem. 2008 Mar 1;16(5):2243-60. doi: 10.1016/j.bmc.2007.11.073. Epub 2007 Dec 3. Bioorg Med Chem. 2008. PMID: 18077174

10

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.

Saitoh M, Kunitomo J, Kimura E, Iwashita H, Uno Y, Onishi T, Uchiyama N, Kawamoto T, Tanaka T, Mol CD, Dougan DR, Textor GP, Snell GP, Takizawa M, Itoh F, Kori M. Saitoh M, et al. Among authors: tanaka t. J Med Chem. 2009 Oct 22;52(20):6270-86. doi: 10.1021/jm900647e. J Med Chem. 2009. PMID: 19775160

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