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Parathyroid tumor development involves deregulation of homeobox genes.
Shen HC, Rosen JE, Yang LM, Savage SA, Burns AL, Mateo CM, Agarwal SK, Chandrasekharappa SC, Spiegel AM, Collins FS, Marx SJ, Libutti SK. Shen HC, et al. Among authors: spiegel am. Endocr Relat Cancer. 2008 Mar;15(1):267-75. doi: 10.1677/ERC-07-0191. Endocr Relat Cancer. 2008. PMID: 18310293 Free PMC article.
The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.
Ozawa A, Agarwal SK, Mateo CM, Burns AL, Rice TS, Kennedy PA, Quigley CM, Simonds WF, Weinstein LS, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. Ozawa A, et al. Among authors: spiegel am. J Clin Endocrinol Metab. 2007 May;92(5):1948-51. doi: 10.1210/jc.2006-2563. Epub 2007 Feb 13. J Clin Endocrinol Metab. 2007. PMID: 17299066
Somatic mutation of the MEN1 gene in parathyroid tumours.
Heppner C, Kester MB, Agarwal SK, Debelenko LV, Emmert-Buck MR, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Doppman JL, Alexander RH, Kim YS, Saggar SK, Lubensky IA, Zhuang Z, Liotta LA, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL, Marx SJ. Heppner C, et al. Among authors: spiegel am. Nat Genet. 1997 Aug;16(4):375-8. doi: 10.1038/ng0897-375. Nat Genet. 1997. PMID: 9241276
Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.
Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, Park WS, Agarwal SK, Debelenko LV, Kester M, Guru SC, Manickam P, Olufemi SE, Yu F, Heppner C, Crabtree JS, Skarulis MC, Venzon DJ, Emmert-Buck MR, Spiegel AM, Chandrasekharappa SC, Collins FS, Burns AL, Marx SJ, Lubensky IA, et al. Zhuang Z, et al. Among authors: spiegel am. Cancer Res. 1997 Nov 1;57(21):4682-6. Cancer Res. 1997. PMID: 9354421
Mutations of the MEN1 tumor suppressor gene in pituitary tumors.
Zhuang Z, Ezzat SZ, Vortmeyer AO, Weil R, Oldfield EH, Park WS, Pack S, Huang S, Agarwal SK, Guru SC, Manickam P, Debelenko LV, Kester MB, Olufemi SE, Heppner C, Crabtree JS, Burns AL, Spiegel AM, Marx SJ, Chandrasekharappa SC, Collins FS, Emmert-Buck MR, Liotta LA, Asa SL, Lubensky IA. Zhuang Z, et al. Among authors: spiegel am. Cancer Res. 1997 Dec 15;57(24):5446-51. Cancer Res. 1997. PMID: 9407947
372 results