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Page 1
Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives.
Knijnenburg AD, Kapoerchan VV, Grotenbreg GM, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, Ravensbergen B, Nibbering PH, van der Marel GA, Overkleeft HS, Overhand M. Knijnenburg AD, et al. Bioorg Med Chem. 2011 Jun 1;19(11):3402-9. doi: 10.1016/j.bmc.2011.04.031. Epub 2011 Apr 22. Bioorg Med Chem. 2011. PMID: 21561781
'Inverted' analogs of the antibiotic gramicidin S with an improved biological profile.
Kapoerchan VV, Knijnenburg AD, Keizer P, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Kapoerchan VV, et al. Among authors: knijnenburg ad. Bioorg Med Chem. 2012 Oct 15;20(20):6059-62. doi: 10.1016/j.bmc.2012.08.038. Epub 2012 Aug 31. Bioorg Med Chem. 2012. PMID: 22989907
An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity.
Kapoerchan VV, Knijnenburg AD, Niamat M, Spalburg E, de Neeling AJ, Nibbering PH, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Kapoerchan VV, et al. Among authors: knijnenburg ad. Chemistry. 2010 Oct 25;16(40):12174-81. doi: 10.1002/chem.201001686. Chemistry. 2010. PMID: 20848624
Exploring the conformational and biological versatility of β-turn-modified gramicidin S by using sugar amino acid homologues that vary in ring size.
Knijnenburg AD, Tuin AW, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Knijnenburg AD, et al. Chemistry. 2011 Mar 28;17(14):3995-4004. doi: 10.1002/chem.201002895. Epub 2011 Mar 1. Chemistry. 2011. PMID: 21365698