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A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. Yamamoto T, et al. Among authors: vagner j. J Med Chem. 2008 Mar 13;51(5):1369-76. doi: 10.1021/jm070332f. Epub 2008 Feb 12. J Med Chem. 2008. PMID: 18266313 Free PMC article.
Opioid and melanocortin receptors: do they have overlapping pharmacophores?
Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Lee YS, et al. Among authors: vagner j. Biopolymers. 2008;90(3):433-8. doi: 10.1002/bip.20814. Biopolymers. 2008. PMID: 17657709 Free PMC article.
Rigid linkers for bioactive peptides.
Vagner J, Handl HL, Monguchi Y, Jana U, Begay LJ, Mash EA, Hruby VJ, Gillies RJ. Vagner J, et al. Bioconjug Chem. 2006 Nov-Dec;17(6):1545-50. doi: 10.1021/bc060154p. Bioconjug Chem. 2006. PMID: 17105235 Free PMC article.
Squalene-derived flexible linkers for bioactive peptides.
Jagadish B, Sankaranarayanan R, Xu L, Richards R, Vagner J, Hruby VJ, Gillies RJ, Mash EA. Jagadish B, et al. Among authors: vagner j. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3310-3. doi: 10.1016/j.bmcl.2007.04.001. Epub 2007 Apr 6. Bioorg Med Chem Lett. 2007. PMID: 17448660 Free PMC article.
107 results