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New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.
Martínez-Esparza J, Oficialdegui AM, Pérez-Silanes S, Heras B, Orús L, Palop JA, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC, Tordera R, Del Río J, Monge A. Martínez-Esparza J, et al. J Med Chem. 2001 Feb 1;44(3):418-28. doi: 10.1021/jm001059j. J Med Chem. 2001. PMID: 11462981
Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.
Orús L, Pérez-Silanes S, Oficialdegui AM, Martínez-Esparza J, Del Castillo JC, Mourelle M, Langer T, Guccione S, Donzella G, Krovat EM, Poptodorov K, Lasheras B, Ballaz S, Hervías I, Tordera R, Del Río J, Monge A. Orús L, et al. J Med Chem. 2002 Sep 12;45(19):4128-39. doi: 10.1021/jm0111200. J Med Chem. 2002. PMID: 12213056
Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues.
Burguete A, Pontiki E, Hadjipavlou-Litina D, Villar R, Vicente E, Solano B, Ancizu S, Pérez-Silanes S, Aldana I, Monge A. Burguete A, et al. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6439-43. doi: 10.1016/j.bmcl.2007.10.002. Epub 2007 Oct 5. Bioorg Med Chem Lett. 2007. PMID: 17942306
58 results