Williams DL - Search Results

1

Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.

Simeonov A, Jadhav A, Sayed AA, Wang Y, Nelson ME, Thomas CJ, Inglese J, Williams DL, Austin CP. Simeonov A, et al. Among authors: williams dl. PLoS Negl Trop Dis. 2008 Jan 2;2(1):e127. doi: 10.1371/journal.pntd.0000127. PLoS Negl Trop Dis. 2008. PMID: 18235848 Free PMC article.

2

Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin.

Alger HM, Sayed AA, Stadecker MJ, Williams DL. Alger HM, et al. Among authors: williams dl. Int J Parasitol. 2002 Sep;32(10):1285-92. doi: 10.1016/s0020-7519(02)00108-x. Int J Parasitol. 2002. PMID: 12204228

3

Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni.

Sayed AA, Williams DL. Sayed AA, et al. Among authors: williams dl. J Biol Chem. 2004 Jun 18;279(25):26159-66. doi: 10.1074/jbc.M401748200. Epub 2004 Apr 9. J Biol Chem. 2004. PMID: 15075328 Free article.

4

Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets.

Sayed AA, Cook SK, Williams DL. Sayed AA, et al. Among authors: williams dl. J Biol Chem. 2006 Jun 23;281(25):17001-17010. doi: 10.1074/jbc.M512601200. Epub 2006 Apr 10. J Biol Chem. 2006. PMID: 16606626 Free article.

5

Schistosoma mansoni albumin, a major defense against oxidative damage, was acquired by lateral gene transfer from a mammalian host.

Williams DL, Sayed AA, Ray D, McArthur AG. Williams DL, et al. Mol Biochem Parasitol. 2006 Dec;150(2):359-63. doi: 10.1016/j.molbiopara.2006.07.009. Epub 2006 Aug 10. Mol Biochem Parasitol. 2006. PMID: 16934344 No abstract available.

6

Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE).

Williams DL, Sayed AA, Bernier J, Birkeland SR, Cipriano MJ, Papa AR, McArthur AG, Taft A, Vermeire JJ, Yoshino TP. Williams DL, et al. Exp Parasitol. 2007 Nov;117(3):246-58. doi: 10.1016/j.exppara.2007.05.001. Epub 2007 May 13. Exp Parasitol. 2007. PMID: 17577588 Free PMC article.

7

Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.

Kuntz AN, Davioud-Charvet E, Sayed AA, Califf LL, Dessolin J, Arnér ES, Williams DL. Kuntz AN, et al. Among authors: williams dl. PLoS Med. 2007 Jun;4(6):e206. doi: 10.1371/journal.pmed.0040206. PLoS Med. 2007. PMID: 17579510 Free PMC article.

8

Identification of oxadiazoles as new drug leads for the control of schistosomiasis.

Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL. Sayed AA, et al. Among authors: williams dl. Nat Med. 2008 Apr;14(4):407-12. doi: 10.1038/nm1737. Epub 2008 Mar 16. Nat Med. 2008. PMID: 18345010 Free PMC article.

9

A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.

Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. Lea WA, et al. Among authors: williams dl. Assay Drug Dev Technol. 2008 Aug;6(4):551-5. doi: 10.1089/adt.2008.149. Assay Drug Dev Technol. 2008. PMID: 18665782 Free PMC article.

10

Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.

Donnelly S, Stack CM, O'Neill SM, Sayed AA, Williams DL, Dalton JP. Donnelly S, et al. Among authors: williams dl. FASEB J. 2008 Nov;22(11):4022-32. doi: 10.1096/fj.08-106278. Epub 2008 Aug 15. FASEB J. 2008. PMID: 18708590 Free PMC article.

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