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Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.
Jarosz-Griffiths HH, Corbett NJ, Rowland HA, Fisher K, Jones AC, Baron J, Howell GJ, Cowley SA, Chintawar S, Cader MZ, Kellett KAB, Hooper NM. Jarosz-Griffiths HH, et al. Among authors: rowland ha. J Biol Chem. 2019 Apr 26;294(17):7085-7097. doi: 10.1074/jbc.RA118.005364. Epub 2019 Mar 14. J Biol Chem. 2019. PMID: 30872401 Free PMC article.
Changes in iPSC-Astrocyte morphology reflect Alzheimer's disease patient clinical markers.
Rowland HA, Miller G, Liu Q, Li S, Sharp NR, Ng B, Wei T, Arunasalam K, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Kocagoncu E, Lawson J, Malhotra P, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Zetterberg H, Cader MZ, Wade-Martins R, Lovestone S, Nevado-Holgado A, Kormilitzin A, Buckley NJ. Rowland HA, et al. Stem Cells. 2024 Dec 20:sxae085. doi: 10.1093/stmcls/sxae085. Online ahead of print. Stem Cells. 2024. PMID: 39704342
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.
Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R. Ng B, et al. Among authors: rowland ha. Brain Commun. 2022 Oct 21;4(6):fcac267. doi: 10.1093/braincomms/fcac267. eCollection 2022. Brain Commun. 2022. PMID: 36349119 Free PMC article.
51 results