Fourie AM - Search Results

1

Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.

Whittle BJ, Varga C, Berko A, Horvath K, Posa A, Riley JP, Lundeen KA, Fourie AM, Dunford PJ. Whittle BJ, et al. Among authors: fourie am. Br J Pharmacol. 2008 Mar;153(5):983-91. doi: 10.1038/sj.bjp.0707645. Epub 2007 Dec 24. Br J Pharmacol. 2008. PMID: 18157165 Free PMC article.

2

Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells.

Lundeen KA, Sun B, Karlsson L, Fourie AM. Lundeen KA, et al. Among authors: fourie am. J Immunol. 2006 Sep 1;177(5):3439-47. doi: 10.4049/jimmunol.177.5.3439. J Immunol. 2006. PMID: 16920986

3

Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton.

Rao NL, Dunford PJ, Xue X, Jiang X, Lundeen KA, Coles F, Riley JP, Williams KN, Grice CA, Edwards JP, Karlsson L, Fourie AM. Rao NL, et al. Among authors: fourie am. J Pharmacol Exp Ther. 2007 Jun;321(3):1154-60. doi: 10.1124/jpet.106.115436. Epub 2007 Mar 19. J Pharmacol Exp Ther. 2007. PMID: 17371808

4

A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker.

Crawford S, Belajic D, Wei J, Riley JP, Dunford PJ, Bembenek S, Fourie A, Edwards JP, Karlsson L, Brunmark A, Wolin RL, Blevitt JM. Crawford S, et al. Mol Cancer Ther. 2008 Mar;7(3):492-9. doi: 10.1158/1535-7163.MCT-07-0307. Mol Cancer Ther. 2008. PMID: 18347137

5

Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Grice CA, Tays KL, Savall BM, Wei J, Butler CR, Axe FU, Bembenek SD, Fourie AM, Dunford PJ, Lundeen K, Coles F, Xue X, Riley JP, Williams KN, Karlsson L, Edwards JP. Grice CA, et al. Among authors: fourie am. J Med Chem. 2008 Jul 24;51(14):4150-69. doi: 10.1021/jm701575k. Epub 2008 Jun 28. J Med Chem. 2008. PMID: 18588282

6

Leukotriene A(4) hydrolase inhibition attenuates allergic airway inflammation and hyperresponsiveness.

Rao NL, Riley JP, Banie H, Xue X, Sun B, Crawford S, Lundeen KA, Yu F, Karlsson L, Fourie AM, Dunford PJ. Rao NL, et al. Among authors: fourie am. Am J Respir Crit Care Med. 2010 May 1;181(9):899-907. doi: 10.1164/rccm.200807-1158OC. Epub 2010 Jan 28. Am J Respir Crit Care Med. 2010. PMID: 20110560

7

Azabenzthiazole inhibitors of leukotriene A₄ hydrolase.

Tanis VM, Bacani GM, Blevitt JM, Chrovian CC, Crawford S, De Leon A, Fourie AM, Gomez L, Grice CA, Herman K, Kearney AM, Landry-Bayle AM, Lee-Dutra A, Nelson J, Riley JP, Santillán A Jr, Wiener JJ, Xue X, Young AL. Tanis VM, et al. Among authors: fourie am. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7504-11. doi: 10.1016/j.bmcl.2012.10.036. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23127888

8

Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase.

Eccles W, Blevitt JM, Booker JN, Chrovian CC, Crawford S, de Leon AR, Deng X, Fourie AM, Grice CA, Herman K, Karlsson L, Kearney AM, Lee-Dutra A, Liang J, Luna R, Pippel D, Rao N, Riley JP, Santillán A, Savall B, Tanis VM, Xue X, Young AL. Eccles W, et al. Among authors: fourie am. Bioorg Med Chem Lett. 2013 Feb 1;23(3):811-5. doi: 10.1016/j.bmcl.2012.11.074. Epub 2012 Dec 5. Bioorg Med Chem Lett. 2013. PMID: 23260350

9

Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase.

Fourie AM. Fourie AM. Curr Opin Investig Drugs. 2009 Nov;10(11):1173-82. Curr Opin Investig Drugs. 2009. PMID: 19876785 Review.

10

Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma.

Barchuk W, Lambert J, Fuhr R, Jiang JZ, Bertelsen K, Fourie A, Liu X, Silkoff PE, Barnathan ES, Thurmond R. Barchuk W, et al. Pulm Pharmacol Ther. 2014 Oct;29(1):15-23. doi: 10.1016/j.pupt.2014.06.003. Epub 2014 Jul 10. Pulm Pharmacol Ther. 2014. PMID: 25018015 Clinical Trial.

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