Johnson SM - Search Results

1

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. J Med Chem. 2008 Jan 24;51(2):260-70. doi: 10.1021/jm0708735. Epub 2007 Dec 21. J Med Chem. 2008. PMID: 18095641

2

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.

Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. Johnson SM, et al. J Med Chem. 2005 Mar 10;48(5):1576-87. doi: 10.1021/jm049274d. J Med Chem. 2005. PMID: 15743199

3

Kinetic stabilization of an oligomeric protein by a single ligand binding event.

Wiseman RL, Johnson SM, Kelker MS, Foss T, Wilson IA, Kelly JW. Wiseman RL, et al. Among authors: johnson sm. J Am Chem Soc. 2005 Apr 20;127(15):5540-51. doi: 10.1021/ja042929f. J Am Chem Soc. 2005. PMID: 15826192

4

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state.

Petrassi HM, Johnson SM, Purkey HE, Chiang KP, Walkup T, Jiang X, Powers ET, Kelly JW. Petrassi HM, et al. Among authors: johnson sm. J Am Chem Soc. 2005 May 11;127(18):6662-71. doi: 10.1021/ja044351f. J Am Chem Soc. 2005. PMID: 15869287

5

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

Johnson SM, Wiseman RL, Sekijima Y, Green NS, Adamski-Werner SL, Kelly JW. Johnson SM, et al. Acc Chem Res. 2005 Dec;38(12):911-21. doi: 10.1021/ar020073i. Acc Chem Res. 2005. PMID: 16359163 Review.

6

Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. J Med Chem. 2008 Oct 23;51(20):6348-58. doi: 10.1021/jm800435s. Epub 2008 Sep 24. J Med Chem. 2008. PMID: 18811132 Free PMC article.

7

Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Johnson SM, Connelly S, Wilson IA, Kelly JW. Johnson SM, et al. J Med Chem. 2009 Feb 26;52(4):1115-25. doi: 10.1021/jm801347s. J Med Chem. 2009. PMID: 19191553 Free PMC article.

8

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.

Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. Choi S, et al. Among authors: johnson sm. J Am Chem Soc. 2010 Feb 3;132(4):1359-70. doi: 10.1021/ja908562q. J Am Chem Soc. 2010. PMID: 20043671 Free PMC article.

9

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.

Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA. Connelly S, et al. Among authors: johnson sm. Curr Opin Struct Biol. 2010 Feb;20(1):54-62. doi: 10.1016/j.sbi.2009.12.009. Epub 2010 Feb 3. Curr Opin Struct Biol. 2010. PMID: 20133122 Free PMC article. Review.

10

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.

Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW. Johnson SM, et al. J Mol Biol. 2012 Aug 10;421(2-3):185-203. doi: 10.1016/j.jmb.2011.12.060. Epub 2012 Jan 5. J Mol Biol. 2012. PMID: 22244854 Free PMC article. Review.

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