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Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action.
Biswas S, Zhang S, Fernandez F, Ghosh B, Zhen J, Kuzhikandathil E, Reith ME, Dutta AK. Biswas S, et al. Among authors: kuzhikandathil e. J Med Chem. 2008 Jan 10;51(1):101-17. doi: 10.1021/jm070860r. Epub 2007 Dec 12. J Med Chem. 2008. PMID: 18072730
Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.
Biswas S, Hazeldine S, Ghosh B, Parrington I, Kuzhikandathil E, Reith ME, Dutta AK. Biswas S, et al. Among authors: kuzhikandathil e. J Med Chem. 2008 May 22;51(10):3005-19. doi: 10.1021/jm701524h. Epub 2008 Apr 12. J Med Chem. 2008. PMID: 18410082
Interaction of D₃ preferring agonist (-)-N⁶-(2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264) with cloned human D₂L, D₂S, and D₃ receptors: potent stimulation of mitogen-activated protein kinases and G protein-coupled inward rectifier potassium channels.
Kuzhikandathil EV, Cote S, Santra S, Dutta AK. Kuzhikandathil EV, et al. Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):97-105. doi: 10.1007/s00210-012-0811-6. Epub 2012 Nov 20. Naunyn Schmiedebergs Arch Pharmacol. 2013. PMID: 23160988 Free PMC article.
41 results