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Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives.
Khomutov M, Hyvönen MT, Simonian A, Formanovsky AA, Mikhura IV, Chizhov AO, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR. Khomutov M, et al. Among authors: alhonen l. J Med Chem. 2019 Dec 26;62(24):11335-11347. doi: 10.1021/acs.jmedchem.9b01666. Epub 2019 Dec 13. J Med Chem. 2019. PMID: 31765147 Free PMC article.
Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.
Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN. Khomutov MA, et al. Among authors: alhonen l. Biochemistry (Mosc). 2013 Dec;78(13):1431-46. doi: 10.1134/S0006297913130051. Biochemistry (Mosc). 2013. PMID: 24490733 Free article. Review.
Targeted disruption of spermidine/spermine N1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues.
Niiranen K, Pietilä M, Pirttilä TJ, Järvinen A, Halmekytö M, Korhonen VP, Keinänen TA, Alhonen L, Jänne J. Niiranen K, et al. Among authors: alhonen l. J Biol Chem. 2002 Jul 12;277(28):25323-8. doi: 10.1074/jbc.M203599200. Epub 2002 May 8. J Biol Chem. 2002. PMID: 12000764 Free article.
A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism.
Rasanen TL, Alhonen L, Sinervirta R, Keinanen T, Herzig KH, Suppola S, Khomutov AR, Vepsalainen J, Janne J. Rasanen TL, et al. Among authors: alhonen l. J Biol Chem. 2002 Oct 18;277(42):39867-72. doi: 10.1074/jbc.M205967200. Epub 2002 Aug 13. J Biol Chem. 2002. PMID: 12181316 Free article.
We recently generated a transgenic rat model for acute pancreatitis, which was apparently caused by a massive depletion of pancreatic polyamines spermidine and spermine due to inducible activation of their catabolism (Alhonen, L., Parkkinen, J. J., Keinanen, T., Sin …
We recently generated a transgenic rat model for acute pancreatitis, which was apparently caused by a massive depletion of pancreatic polyam …
177 results