Seligsohn U - Search Results

1

Disulfide bond disruption by a beta 3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active alpha IIb beta 3.

Mor-Cohen R, Rosenberg N, Peretz H, Landau M, Coller BS, Awidi A, Seligsohn U. Mor-Cohen R, et al. Among authors: seligsohn u. Thromb Haemost. 2007 Dec;98(6):1257-65. Thromb Haemost. 2007. PMID: 18064323

2

Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus.

Rosenberg N, Yatuv R, Sobolev V, Peretz H, Zivelin A, Seligsohn U. Rosenberg N, et al. Among authors: seligsohn u. Blood. 2003 Jun 15;101(12):4808-15. doi: 10.1182/blood-2002-08-2452. Epub 2003 Feb 27. Blood. 2003. PMID: 12609844 Free article.

3

Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation.

Fromovich-Amit Y, Zivelin A, Rosenberg N, Landau M, Rosa JP, Seligsohn U. Fromovich-Amit Y, et al. Among authors: seligsohn u. Blood Coagul Fibrinolysis. 2005 Jul;16(5):369-74. doi: 10.1097/01.mbc.0000172696.62363.8c. Blood Coagul Fibrinolysis. 2005. PMID: 15970722

4

Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3).

Peretz H, Rosenberg N, Landau M, Usher S, Nelson EJ, Mor-Cohen R, French DL, Mitchell BW, Nair SC, Chandy M, Coller BS, Srivastava A, Seligsohn U. Peretz H, et al. Among authors: seligsohn u. Hum Mutat. 2006 Apr;27(4):359-69. doi: 10.1002/humu.20304. Hum Mutat. 2006. PMID: 16463284

5

Specific cysteines in beta3 are involved in disulfide bond exchange-dependent and -independent activation of alphaIIbbeta3.

Mor-Cohen R, Rosenberg N, Landau M, Lahav J, Seligsohn U. Mor-Cohen R, et al. Among authors: seligsohn u. J Biol Chem. 2008 Jul 11;283(28):19235-44. doi: 10.1074/jbc.M802399200. Epub 2008 May 5. J Biol Chem. 2008. PMID: 18458089 Free article.

6

Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner.

Mor-Cohen R, Rosenberg N, Einav Y, Zelzion E, Landau M, Mansour W, Averbukh Y, Seligsohn U. Mor-Cohen R, et al. Among authors: seligsohn u. J Biol Chem. 2012 Mar 16;287(12):8879-91. doi: 10.1074/jbc.M111.311043. Epub 2012 Feb 3. J Biol Chem. 2012. PMID: 22308022 Free PMC article.

7

Disulfide bond exchanges in integrins αIIbβ3 and αvβ3 are required for activation and post-ligation signaling during clot retraction.

Mor-Cohen R, Rosenberg N, Averbukh Y, Seligsohn U, Lahav J. Mor-Cohen R, et al. Among authors: seligsohn u. Thromb Res. 2014 May;133(5):826-36. doi: 10.1016/j.thromres.2014.02.001. Epub 2014 Feb 7. Thromb Res. 2014. PMID: 24560420

8

Abnormal cytoplasmic extensions associated with active αIIbβ3 are probably the cause for macrothrombocytopenia in Glanzmann thrombasthenia-like syndrome.

Hauschner H, Mor-Cohen R, Messineo S, Mansour W, Seligsohn U, Savoia A, Rosenberg N. Hauschner H, et al. Among authors: seligsohn u. Blood Coagul Fibrinolysis. 2015 Apr;26(3):302-8. doi: 10.1097/MBC.0000000000000241. Blood Coagul Fibrinolysis. 2015. PMID: 25806962

9

The role of protein disulfide isomerase in the post-ligation phase of β3 integrin-dependent cell adhesion.

Leader A, Mor-Cohen R, Ram R, Sheptovitsky V, Seligsohn U, Rosenberg N, Lahav J. Leader A, et al. Among authors: seligsohn u. Thromb Res. 2015 Dec;136(6):1259-65. doi: 10.1016/j.thromres.2015.10.030. Epub 2015 Oct 17. Thromb Res. 2015. PMID: 26514956

10

Low Concentrations of Recombinant Factor VIIa May Improve the Impaired Thrombin Generation of Glanzmann Thrombasthenia Patients.

Levy-Mendelovich S, Levy T, Budnik I, Barg AA, Rosenberg N, Seligsohn U, Kenet G, Livnat T. Levy-Mendelovich S, et al. Among authors: seligsohn u. Thromb Haemost. 2019 Jan;119(1):117-127. doi: 10.1055/s-0038-1676348. Epub 2018 Dec 31. Thromb Haemost. 2019. PMID: 30597506

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