Chung RP - Search Results

1

A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.

Dhagat U, Carbone V, Chung RP, Matsunaga T, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Among authors: chung rp. Med Chem. 2007 Nov;3(6):546-50. doi: 10.2174/157340607782360399. Med Chem. 2007. PMID: 18045204

2

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.

Carbone V, Chung R, Endo S, Hara A, El-Kabbani O. Carbone V, et al. Arch Biochem Biophys. 2008 Nov 1;479(1):82-7. doi: 10.1016/j.abb.2008.08.014. Epub 2008 Aug 28. Arch Biochem Biophys. 2008. PMID: 18782556

3

Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.

Carbone V, Zhao HT, Chung R, Endo S, Hara A, El-Kabbani O. Carbone V, et al. Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. doi: 10.1016/j.bmc.2008.12.024. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19121944

4

Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.

Dhagat U, Carbone V, Chung RP, Schulze-Briese C, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Among authors: chung rp. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):825-30. doi: 10.1107/S1744309107040985. Epub 2007 Sep 19. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17909281 Free PMC article.

5

Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor.

Carbone V, Giglio M, Chung R, Huyton T, Adams J, Maccari R, Ottana R, Hara A, El-Kabbani O. Carbone V, et al. Eur J Med Chem. 2010 Mar;45(3):1140-5. doi: 10.1016/j.ejmech.2009.12.019. Epub 2009 Dec 21. Eur J Med Chem. 2010. PMID: 20036445

6

Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis.

Sundaram K, Dhagat U, Endo S, Chung R, Matsunaga T, Hara A, El-Kabbani O. Sundaram K, et al. Bioorg Med Chem Lett. 2011 Jan 15;21(2):801-4. doi: 10.1016/j.bmcl.2010.11.086. Epub 2010 Nov 24. Bioorg Med Chem Lett. 2011. PMID: 21168333

7

Sorbitol dehydrogenase: structure, function and ligand design.

El-Kabbani O, Darmanin C, Chung RP. El-Kabbani O, et al. Among authors: chung rp. Curr Med Chem. 2004 Feb;11(4):465-76. doi: 10.2174/0929867043455927. Curr Med Chem. 2004. PMID: 14965227 Review.

8

Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme.

El-Kabbani O, Ramsland P, Darmanin C, Chung RP, Podjarny A. El-Kabbani O, et al. Among authors: chung rp. Proteins. 2003 Feb 1;50(2):230-8. doi: 10.1002/prot.10278. Proteins. 2003. PMID: 12486717

9

Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.

El-Kabbani O, Ishikura S, Darmanin C, Carbone V, Chung RP, Usami N, Hara A. El-Kabbani O, et al. Among authors: chung rp. Proteins. 2004 May 15;55(3):724-32. doi: 10.1002/prot.20047. Proteins. 2004. PMID: 15103634

10

Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

El-Kabbani O, Carbone V, Darmanin C, Oka M, Mitschler A, Podjarny A, Schulze-Briese C, Chung RP. El-Kabbani O, et al. Among authors: chung rp. J Med Chem. 2005 Aug 25;48(17):5536-42. doi: 10.1021/jm050412o. J Med Chem. 2005. PMID: 16107153

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