Carbone V - Search Results

1

A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.

Dhagat U, Carbone V, Chung RP, Matsunaga T, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Among authors: carbone v. Med Chem. 2007 Nov;3(6):546-50. doi: 10.2174/157340607782360399. Med Chem. 2007. PMID: 18045204

2

Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme.

Carbone V, Darmanin C, Ishikura S, Hara A, El-Kabbani O. Carbone V, et al. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1469-74. doi: 10.1016/s0960-894x(03)00166-5. Bioorg Med Chem Lett. 2003. PMID: 12668014

3

Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking.

Carbone V, Ishikura S, Hara A, El-Kabbani O. Carbone V, et al. Bioorg Med Chem. 2005 Jan 17;13(2):301-12. doi: 10.1016/j.bmc.2004.10.030. Bioorg Med Chem. 2005. PMID: 15598553

4

Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

El-Kabbani O, Carbone V, Darmanin C, Oka M, Mitschler A, Podjarny A, Schulze-Briese C, Chung RP. El-Kabbani O, et al. Among authors: carbone v. J Med Chem. 2005 Aug 25;48(17):5536-42. doi: 10.1021/jm050412o. J Med Chem. 2005. PMID: 16107153

5

Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.

Dhagat U, Carbone V, Chung RP, Schulze-Briese C, Endo S, Hara A, El-Kabbani O. Dhagat U, et al. Among authors: carbone v. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):825-30. doi: 10.1107/S1744309107040985. Epub 2007 Sep 19. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17909281 Free PMC article.

6

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.

Carbone V, Chung R, Endo S, Hara A, El-Kabbani O. Carbone V, et al. Arch Biochem Biophys. 2008 Nov 1;479(1):82-7. doi: 10.1016/j.abb.2008.08.014. Epub 2008 Aug 28. Arch Biochem Biophys. 2008. PMID: 18782556

7

Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.

Carbone V, Zhao HT, Chung R, Endo S, Hara A, El-Kabbani O. Carbone V, et al. Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. doi: 10.1016/j.bmc.2008.12.024. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19121944

8

Structural and functional features of dimeric dihydrodiol dehydrogenase.

Carbone V, Hara A, El-Kabbani O. Carbone V, et al. Cell Mol Life Sci. 2008 May;65(10):1464-74. doi: 10.1007/s00018-008-7508-5. Cell Mol Life Sci. 2008. PMID: 18264804 Free PMC article. Review.

9

Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.

El-Kabbani O, Ishikura S, Darmanin C, Carbone V, Chung RP, Usami N, Hara A. El-Kabbani O, et al. Among authors: carbone v. Proteins. 2004 May 15;55(3):724-32. doi: 10.1002/prot.20047. Proteins. 2004. PMID: 15103634

10

Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.

El-Kabbani O, Carbone V, Darmanin C, Ishikura S, Hara A. El-Kabbani O, et al. Among authors: carbone v. Proteins. 2005 Aug 15;60(3):424-32. doi: 10.1002/prot.20487. Proteins. 2005. PMID: 15906319

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