Pichardo J - Search Results

1

Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue.

Chen KX, Vibulbhan B, Yang W, Cheng KC, Liu R, Pichardo J, Butkiewicz N, Njoroge FG. Chen KX, et al. Among authors: pichardo j. Bioorg Med Chem. 2008 Feb 15;16(4):1874-83. doi: 10.1016/j.bmc.2007.11.002. Epub 2007 Nov 5. Bioorg Med Chem. 2008. PMID: 18032054

2

Novel inhibitors of the hepatitis C virus NS3 proteinase.

Bennett F, Liu YT, Saksena AK, Arasappan A, Butkiewicz N, Dasmahapatra B, Pichardo JS, Njoroge FG, Patel NM, Huang Y, Yang X. Bennett F, et al. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4275-8. doi: 10.1016/j.bmcl.2005.06.079. Bioorg Med Chem Lett. 2005. PMID: 16087334

3

Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.

Arasappan A, Njoroge FG, Parekh TN, Yang X, Pichardo J, Butkiewicz N, Prongay A, Yao N, Girijavallabhan V. Arasappan A, et al. Among authors: pichardo j. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5751-5. doi: 10.1016/j.bmcl.2004.09.058. Bioorg Med Chem Lett. 2004. PMID: 15501035

4

Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.

Venkatraman S, Njoroge FG, Girijavallabhan VM, Madison VS, Yao NH, Prongay AJ, Butkiewicz N, Pichardo J. Venkatraman S, et al. Among authors: pichardo j. J Med Chem. 2005 Aug 11;48(16):5088-91. doi: 10.1021/jm0489556. J Med Chem. 2005. PMID: 16078825

5

Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease.

Chen KX, Njoroge FG, Prongay A, Pichardo J, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: pichardo j. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4475-8. doi: 10.1016/j.bmcl.2005.07.033. Bioorg Med Chem Lett. 2005. PMID: 16112859

6

Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.

Chen KX, Njoroge FG, Pichardo J, Prongay A, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: pichardo j. J Med Chem. 2005 Oct 6;48(20):6229-35. doi: 10.1021/jm050323b. J Med Chem. 2005. PMID: 16190750

7

Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity.

Chen KX, Njoroge FG, Vibulbhan B, Prongay A, Pichardo J, Madison V, Buevich A, Chan TM. Chen KX, et al. Among authors: pichardo j. Angew Chem Int Ed Engl. 2005 Nov 4;44(43):7024-8. doi: 10.1002/anie.200501553. Angew Chem Int Ed Engl. 2005. PMID: 16211639 No abstract available.

8

Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.

Bogen SL, Ruan S, Liu R, Agrawal S, Pichardo J, Prongay A, Baroudy B, Saksena AK, Girijavallabhan V, Njoroge FG. Bogen SL, et al. Among authors: pichardo j. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1621-7. doi: 10.1016/j.bmcl.2005.12.013. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16387495

9

Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid.

Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J. Venkatraman S, et al. Among authors: pichardo j. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. doi: 10.1016/j.bmcl.2005.12.046. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413182

10

Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.

Chen KX, Njoroge FG, Pichardo J, Prongay A, Butkiewicz N, Yao N, Madison V, Girijavallabhan V. Chen KX, et al. Among authors: pichardo j. J Med Chem. 2006 Jan 26;49(2):567-74. doi: 10.1021/jm050520a. J Med Chem. 2006. PMID: 16420042

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