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179 results

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Page 1
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.
Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, Vidović D, Schürer S, Branden L, Davis RE, Staudt LM, Inglese J, Austin CP, Landry DW, Smith DH, Auld DS. Xie Y, et al. Among authors: schurer s. Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. doi: 10.1016/j.bmcl.2007.10.100. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 18024113 Free PMC article.
Reversal of Lactate and PD-1-mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer.
Chaudagar K, Hieromnimon HM, Khurana R, Labadie B, Hirz T, Mei S, Hasan R, Shafran J, Kelley A, Apostolov E, Al-Eryani G, Harvey K, Rameshbabu S, Loyd M, Bynoe K, Drovetsky C, Solanki A, Markiewicz E, Zamora M, Fan X, Schürer S, Swarbrick A, Sykes DB, Patnaik A. Chaudagar K, et al. Among authors: schurer s. Clin Cancer Res. 2023 May 15;29(10):1952-1968. doi: 10.1158/1078-0432.CCR-22-3350. Clin Cancer Res. 2023. PMID: 36862086 Free PMC article.
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.
Xie Y, Liu Y, Gong G, Rinderspacher A, Deng SX, Smith DH, Toebben U, Tzilianos E, Branden L, Vidović D, Chung C, Schürer S, Tautz L, Landry DW. Xie Y, et al. Among authors: schurer s. Bioorg Med Chem Lett. 2008 May 1;18(9):2840-4. doi: 10.1016/j.bmcl.2008.03.079. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18434147 Free PMC article.
Benzimidazole- and benzoxazole-based inhibitors of Rho kinase.
Sessions EH, Yin Y, Bannister TD, Weiser A, Griffin E, Pocas J, Cameron MD, Ruiz C, Lin L, Schürer SC, Schröter T, LoGrasso P, Feng Y. Sessions EH, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6390-3. doi: 10.1016/j.bmcl.2008.10.095. Epub 2008 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 18996009
Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.
Rinderspacher A, Cremona ML, Liu Y, Deng SX, Xie Y, Gong G, Aulner N, Többen U, Myers K, Chung C, Andersen M, Vidović D, Schürer S, Brandén L, Yamamoto A, Landry DW. Rinderspacher A, et al. Among authors: schurer s. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1715-7. doi: 10.1016/j.bmcl.2009.01.087. Epub 2009 Jan 30. Bioorg Med Chem Lett. 2009. PMID: 19243939 Free PMC article.
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Xie Y, Liu Y, Gong G, Smith DH, Yan F, Rinderspacher A, Feng Y, Zhu Z, Li X, Deng SX, Branden L, Vidović D, Chung C, Schürer S, Morisseau C, Hammock BD, Landry DW. Xie Y, et al. Among authors: schurer s. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2354-9. doi: 10.1016/j.bmcl.2008.09.066. Epub 2008 Sep 20. Bioorg Med Chem Lett. 2009. PMID: 19303288 Free PMC article.
179 results