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8,238 results

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Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.
Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, Vidović D, Schürer S, Branden L, Davis RE, Staudt LM, Inglese J, Austin CP, Landry DW, Smith DH, Auld DS. Xie Y, et al. Among authors: chung c. Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. doi: 10.1016/j.bmcl.2007.10.100. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 18024113 Free PMC article.
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.
Xie Y, Liu Y, Gong G, Rinderspacher A, Deng SX, Smith DH, Toebben U, Tzilianos E, Branden L, Vidović D, Chung C, Schürer S, Tautz L, Landry DW. Xie Y, et al. Among authors: chung c. Bioorg Med Chem Lett. 2008 May 1;18(9):2840-4. doi: 10.1016/j.bmcl.2008.03.079. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18434147 Free PMC article.
Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.
Rinderspacher A, Cremona ML, Liu Y, Deng SX, Xie Y, Gong G, Aulner N, Többen U, Myers K, Chung C, Andersen M, Vidović D, Schürer S, Brandén L, Yamamoto A, Landry DW. Rinderspacher A, et al. Among authors: chung c. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1715-7. doi: 10.1016/j.bmcl.2009.01.087. Epub 2009 Jan 30. Bioorg Med Chem Lett. 2009. PMID: 19243939 Free PMC article.
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Xie Y, Liu Y, Gong G, Smith DH, Yan F, Rinderspacher A, Feng Y, Zhu Z, Li X, Deng SX, Branden L, Vidović D, Chung C, Schürer S, Morisseau C, Hammock BD, Landry DW. Xie Y, et al. Among authors: chung c. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2354-9. doi: 10.1016/j.bmcl.2008.09.066. Epub 2008 Sep 20. Bioorg Med Chem Lett. 2009. PMID: 19303288 Free PMC article.
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Vang T, Xie Y, Liu WH, Vidović D, Liu Y, Wu S, Smith DH, Rinderspacher A, Chung C, Gong G, Mustelin T, Landry DW, Rickert RC, Schürer SC, Deng SX, Tautz L. Vang T, et al. Among authors: chung c. J Med Chem. 2011 Jan 27;54(2):562-71. doi: 10.1021/jm101004d. Epub 2010 Dec 29. J Med Chem. 2011. PMID: 21190368 Free PMC article.
Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype.
Vidović D, Xie Y, Rinderspacher A, Deng SX, Landry DW, Chung C, Smith DH, Tautz L, Schürer SC. Vidović D, et al. Among authors: chung c. J Comput Aided Mol Des. 2011 Sep;25(9):873-83. doi: 10.1007/s10822-011-9469-2. Epub 2011 Sep 9. J Comput Aided Mol Des. 2011. PMID: 21904909 Free PMC article.
Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS).
Vempati UD, Chung C, Mader C, Koleti A, Datar N, Vidović D, Wrobel D, Erickson S, Muhlich JL, Berriz G, Benes CH, Subramanian A, Pillai A, Shamu CE, Schürer SC. Vempati UD, et al. Among authors: chung c. J Biomol Screen. 2014 Jun;19(5):803-16. doi: 10.1177/1087057114522514. Epub 2014 Feb 11. J Biomol Screen. 2014. PMID: 24518066 Free PMC article.
Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).
Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P. Schröter T, et al. Among authors: chung c. J Biomol Screen. 2008 Jan;13(1):17-28. doi: 10.1177/1087057107310806. J Biomol Screen. 2008. PMID: 18227223
8,238 results