Lepesheva GI - Search Results

1

Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.

Lepesheva GI, Ott RD, Hargrove TY, Kleshchenko YY, Schuster I, Nes WD, Hill GC, Villalta F, Waterman MR. Lepesheva GI, et al. Chem Biol. 2007 Nov;14(11):1283-93. doi: 10.1016/j.chembiol.2007.10.011. Chem Biol. 2007. PMID: 18022567 Free PMC article.

2

Folding requirements are different between sterol 14alpha-demethylase (CYP51) from Mycobacterium tuberculosis and human or fungal orthologs.

Lepesheva GI, Podust LM, Bellamine A, Waterman MR. Lepesheva GI, et al. J Biol Chem. 2001 Jul 27;276(30):28413-20. doi: 10.1074/jbc.M102767200. Epub 2001 May 23. J Biol Chem. 2001. PMID: 11373285 Free article.

3

Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function.

Lepesheva GI, Virus C, Waterman MR. Lepesheva GI, et al. Biochemistry. 2003 Aug 5;42(30):9091-101. doi: 10.1021/bi034663f. Biochemistry. 2003. PMID: 12885242

4

CYP51--the omnipotent P450.

Lepesheva GI, Waterman MR. Lepesheva GI, et al. Mol Cell Endocrinol. 2004 Feb 27;215(1-2):165-70. doi: 10.1016/j.mce.2003.11.016. Mol Cell Endocrinol. 2004. PMID: 15026190 Review.

5

CYP51 from Trypanosoma brucei is obtusifoliol-specific.

Lepesheva GI, Nes WD, Zhou W, Hill GC, Waterman MR. Lepesheva GI, et al. Biochemistry. 2004 Aug 24;43(33):10789-99. doi: 10.1021/bi048967t. Biochemistry. 2004. PMID: 15311940

6

Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology.

Bellamine A, Lepesheva GI, Waterman MR. Bellamine A, et al. Among authors: lepesheva gi. J Lipid Res. 2004 Nov;45(11):2000-7. doi: 10.1194/jlr.M400239-JLR200. Epub 2004 Aug 16. J Lipid Res. 2004. PMID: 15314102 Free article.

7

Estriol bound and ligand-free structures of sterol 14alpha-demethylase.

Podust LM, Yermalitskaya LV, Lepesheva GI, Podust VN, Dalmasso EA, Waterman MR. Podust LM, et al. Among authors: lepesheva gi. Structure. 2004 Nov;12(11):1937-45. doi: 10.1016/j.str.2004.08.009. Structure. 2004. PMID: 15530358 Free article.

8

Sterol 14 alpha-demethylase, an abundant and essential mixed-function oxidase.

Waterman MR, Lepesheva GI. Waterman MR, et al. Among authors: lepesheva gi. Biochem Biophys Res Commun. 2005 Dec 9;338(1):418-22. doi: 10.1016/j.bbrc.2005.08.118. Epub 2005 Aug 24. Biochem Biophys Res Commun. 2005. PMID: 16153595 Review.

9

CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase.

Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. Lepesheva GI, et al. J Biol Chem. 2006 Feb 10;281(6):3577-85. doi: 10.1074/jbc.M510317200. Epub 2005 Nov 30. J Biol Chem. 2006. PMID: 16321980 Free article.

10

Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei.

Zhou W, Lepesheva GI, Waterman MR, Nes WD. Zhou W, et al. Among authors: lepesheva gi. J Biol Chem. 2006 Mar 10;281(10):6290-6. doi: 10.1074/jbc.M511749200. Epub 2006 Jan 12. J Biol Chem. 2006. PMID: 16414960 Free article.

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