Dean DC - Search Results

1

In vitro metabolic activation of lumiracoxib in rat and human liver preparations.

Li Y, Slatter JG, Zhang Z, Li Y, Doss GA, Braun MP, Stearns RA, Dean DC, Baillie TA, Tang W. Li Y, et al. Among authors: dean dc. Drug Metab Dispos. 2008 Feb;36(2):469-73. doi: 10.1124/dmd.107.019018. Epub 2007 Nov 12. Drug Metab Dispos. 2008. PMID: 17998295

2

Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.

Tan EY, Hartmann G, Chen Q, Pereira A, Bradley S, Doss G, Zhang AS, Ho JZ, Braun MP, Dean DC, Tang W, Kumar S. Tan EY, et al. Among authors: dean dc. Drug Metab Dispos. 2010 Mar;38(3):459-73. doi: 10.1124/dmd.109.028696. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016052

3

Validation of (-)-N-3-benzyl-phenobarbital as a selective inhibitor of CYP2C19 in human liver microsomes.

Cai X, Wang RW, Edom RW, Evans DC, Shou M, Rodrigues AD, Liu W, Dean DC, Baillie TA. Cai X, et al. Among authors: dean dc. Drug Metab Dispos. 2004 Jun;32(6):584-6. doi: 10.1124/dmd.32.6.584. Drug Metab Dispos. 2004. PMID: 15155548

4

Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques.

Baillie TA, Halpin RA, Matuszewski BK, Geer LA, Chavez-Eng CM, Dean D, Braun M, Doss G, Jones A, Marks T, Melillo D, Vyas KP. Baillie TA, et al. Drug Metab Dispos. 2001 Dec;29(12):1614-28. Drug Metab Dispos. 2001. PMID: 11717181

5

Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.

Tang W, Stearns RA, Wang RW, Miller RR, Chen Q, Ngui J, Bakshi RK, Nargund RP, Dean DC, Baillie TA. Tang W, et al. Among authors: dean dc. Xenobiotica. 2008 Nov;38(11):1437-51. doi: 10.1080/00498250802464685. Xenobiotica. 2008. PMID: 18841517

6

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA. Tang W, et al. Among authors: dean dc. Drug Metab Dispos. 1999 Mar;27(3):365-72. Drug Metab Dispos. 1999. PMID: 10064567

7

Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans.

Kumar S, Tan EY, Hartmann G, Biddle Z, Bergman AJ, Dru J, Ho JZ, Jones AN, Staskiewicz SJ, Braun MP, Karanam B, Dean DC, Gendrano IN, Graves MW, Wagner JA, Krishna R. Kumar S, et al. Among authors: dean dc. Drug Metab Dispos. 2010 Mar;38(3):474-83. doi: 10.1124/dmd.109.028704. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016053 Clinical Trial.

8

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA. Kassahun K, et al. Chem Res Toxicol. 2001 Jan;14(1):62-70. doi: 10.1021/tx000180q. Chem Res Toxicol. 2001. PMID: 11170509

9

The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs.

Halpin RA, Geer LA, Zhang KE, Marks TM, Dean DC, Jones AN, Melillo D, Doss G, Vyas KP. Halpin RA, et al. Among authors: dean dc. Drug Metab Dispos. 2000 Oct;28(10):1244-54. Drug Metab Dispos. 2000. PMID: 10997947

10

Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.

Balani SK, Xu X, Arison BH, Silva MV, Gries A, DeLuna FA, Cui D, Kari PH, Ly T, Hop CE, Singh R, Wallace MA, Dean DC, Lin JH, Pearson PG, Baillie TA. Balani SK, et al. Among authors: dean dc. Drug Metab Dispos. 2000 Nov;28(11):1274-8. Drug Metab Dispos. 2000. PMID: 11038152

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

268 results

Search Page

Filters