Gokhale V - Search Results

1

Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4.

Qin Y, Rezler EM, Gokhale V, Sun D, Hurley LH. Qin Y, et al. Among authors: gokhale v. Nucleic Acids Res. 2007;35(22):7698-713. doi: 10.1093/nar/gkm538. Epub 2007 Nov 5. Nucleic Acids Res. 2007. PMID: 17984069 Free PMC article.

2

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).

Dexheimer TS, Carey SS, Zuohe S, Gokhale VM, Hu X, Murata LB, Maes EM, Weichsel A, Sun D, Meuillet EJ, Montfort WR, Hurley LH. Dexheimer TS, et al. Mol Cancer Ther. 2009 May;8(5):1363-77. doi: 10.1158/1535-7163.MCT-08-1093. Epub 2009 May 12. Mol Cancer Ther. 2009. PMID: 19435876 Free PMC article.

3

The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.

Seenisamy J, Rezler EM, Powell TJ, Tye D, Gokhale V, Joshi CS, Siddiqui-Jain A, Hurley LH. Seenisamy J, et al. Among authors: gokhale v. J Am Chem Soc. 2004 Jul 21;126(28):8702-9. doi: 10.1021/ja040022b. J Am Chem Soc. 2004. PMID: 15250722

4

Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.

Seenisamy J, Bashyam S, Gokhale V, Vankayalapati H, Sun D, Siddiqui-Jain A, Streiner N, Shin-Ya K, White E, Wilson WD, Hurley LH. Seenisamy J, et al. Among authors: gokhale v. J Am Chem Soc. 2005 Mar 9;127(9):2944-59. doi: 10.1021/ja0444482. J Am Chem Soc. 2005. PMID: 15740131

5

Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene.

Guo K, Pourpak A, Beetz-Rogers K, Gokhale V, Sun D, Hurley LH. Guo K, et al. Among authors: gokhale v. J Am Chem Soc. 2007 Aug 22;129(33):10220-8. doi: 10.1021/ja072185g. Epub 2007 Aug 2. J Am Chem Soc. 2007. PMID: 17672459 Free PMC article.

6

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.

Sun D, Liu WJ, Guo K, Rusche JJ, Ebbinghaus S, Gokhale V, Hurley LH. Sun D, et al. Among authors: gokhale v. Mol Cancer Ther. 2008 Apr;7(4):880-9. doi: 10.1158/1535-7163.MCT-07-2119. Mol Cancer Ther. 2008. PMID: 18413801 Free PMC article.

7

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene.

Guo K, Gokhale V, Hurley LH, Sun D. Guo K, et al. Among authors: gokhale v. Nucleic Acids Res. 2008 Aug;36(14):4598-608. doi: 10.1093/nar/gkn380. Epub 2008 Jul 9. Nucleic Acids Res. 2008. PMID: 18614607 Free PMC article.

8

The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression.

Brown RV, Wang T, Chappeta VR, Wu G, Onel B, Chawla R, Quijada H, Camp SM, Chiang ET, Lassiter QR, Lee C, Phanse S, Turnidge MA, Zhao P, Garcia JGN, Gokhale V, Yang D, Hurley LH. Brown RV, et al. Among authors: gokhale v. J Am Chem Soc. 2017 Jun 7;139(22):7456-7475. doi: 10.1021/jacs.6b10028. Epub 2017 May 19. J Am Chem Soc. 2017. PMID: 28471683 Free PMC article.

9

Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex.

Brown RV, Danford FL, Gokhale V, Hurley LH, Brooks TA. Brown RV, et al. Among authors: gokhale v. J Biol Chem. 2011 Nov 25;286(47):41018-27. doi: 10.1074/jbc.M111.274720. Epub 2011 Sep 28. J Biol Chem. 2011. PMID: 21956115 Free PMC article.

10

Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.

Boddupally PV, Hahn S, Beman C, De B, Brooks TA, Gokhale V, Hurley LH. Boddupally PV, et al. Among authors: gokhale v. J Med Chem. 2012 Jul 12;55(13):6076-86. doi: 10.1021/jm300282c. Epub 2012 Jun 25. J Med Chem. 2012. PMID: 22691117 Free PMC article.

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