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Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT.
Bridgland-Taylor MH, Hargreaves AC, Easter A, Orme A, Henthorn DC, Ding M, Davis AM, Small BG, Heapy CG, Abi-Gerges N, Persson F, Jacobson I, Sullivan M, Albertson N, Hammond TG, Sullivan E, Valentin JP, Pollard CE. Bridgland-Taylor MH, et al. Among authors: easter a. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):189-99. doi: 10.1016/j.vascn.2006.02.003. Epub 2006 Mar 6. J Pharmacol Toxicol Methods. 2006. PMID: 16563806
Approaches to seizure risk assessment in preclinical drug discovery.
Easter A, Bell ME, Damewood JR Jr, Redfern WS, Valentin JP, Winter MJ, Fonck C, Bialecki RA. Easter A, et al. Drug Discov Today. 2009 Sep;14(17-18):876-84. doi: 10.1016/j.drudis.2009.06.003. Epub 2009 Jun 21. Drug Discov Today. 2009. PMID: 19545644 Review.
Incidence of spontaneous arrhythmias in freely moving healthy untreated Sprague-Dawley rats.
Pereira PJS, Pugsley MK, Troncy E, Tan W, Pouliot M, Harper C, Prefontaine A, Easter A, Wallis R, Miraucourt L, Huang H, Accardi MV, Boulay E, Maghezzi MS, Authier S. Pereira PJS, et al. Among authors: easter a. J Pharmacol Toxicol Methods. 2019 Sep-Oct;99:106589. doi: 10.1016/j.vascn.2019.106589. Epub 2019 May 31. J Pharmacol Toxicol Methods. 2019. PMID: 31154034 Free article.
Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.
Scott JS, Bowker SS, Brocklehurst KJ, Brown HS, Clarke DS, Easter A, Ertan A, Goldberg K, Hudson JA, Kavanagh S, Laber D, Leach AG, MacFaul PA, Martin EA, McKerrecher D, Schofield P, Svensson PH, Teague J. Scott JS, et al. Among authors: easter a. J Med Chem. 2014 Nov 13;57(21):8984-98. doi: 10.1021/jm5011012. Epub 2014 Nov 3. J Med Chem. 2014. PMID: 25286150
In silico prediction of hERG inhibition.
Jing Y, Easter A, Peters D, Kim N, Enyedy IJ. Jing Y, et al. Among authors: easter a. Future Med Chem. 2015;7(5):571-86. doi: 10.4155/fmc.15.18. Future Med Chem. 2015. PMID: 25921399 Review.
[No title available]
[No authors listed] [No authors listed] PMID: 31962963
105 results