Qi J - Search Results

1

Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment.

Luci DK, Ghosh S, Smith CE, Qi J, Wang Y, Haertlein B, Parry TJ, Li J, Almond HR Jr, Minor LK, Damiano BP, Kinney WA, Maryanoff BE, Lawson EC. Luci DK, et al. Among authors: qi j. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6489-92. doi: 10.1016/j.bmcl.2007.09.092. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17933531

2

Structure-function analysis of urotensin II and its use in the construction of a ligand-receptor working model.

Kinney WA, Almond HR Jr, Qi J, Smith CE, Santulli RJ, de Garavilla L, Andrade-Gordon P, Cho DS, Everson AM, Feinstein MA, Leung PA, Maryanoff BE. Kinney WA, et al. Among authors: qi j. Angew Chem Int Ed Engl. 2002 Aug 16;41(16):2940-4. doi: 10.1002/1521-3773(20020816)41:16<2940::AID-ANIE2940>3.0.CO;2-M. Angew Chem Int Ed Engl. 2002. PMID: 12203418 No abstract available.

3

Virus-based expression systems facilitate rapid target in vivo functionality validation and high-throughput screening.

Darrow AL, Conway KA, Vaidya AH, Rosenthal D, Wildey MJ, Minor L, Itkin Z, Kong Y, Piesvaux J, Qi J, Mercken M, Andrade-Gordon P, Plata-Salamán C, Ilyin SE. Darrow AL, et al. Among authors: qi j. J Biomol Screen. 2003 Feb;8(1):65-71. doi: 10.1177/1087057102239664. J Biomol Screen. 2003. PMID: 12854999

4

Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.

Lawson EC, Luci DK, Ghosh S, Kinney WA, Reynolds CH, Qi J, Smith CE, Wang Y, Minor LK, Haertlein BJ, Parry TJ, Damiano BP, Maryanoff BE. Lawson EC, et al. Among authors: qi j. J Med Chem. 2009 Dec 10;52(23):7432-45. doi: 10.1021/jm900683d. J Med Chem. 2009. PMID: 19731961

5

High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity.

Qi J, Lang W, Giardino E, Caldwell GW, Smith C, Minor LK, Darrow AL, Willemsens G, Dewaepenaert K, Roevens P, Linders JT, Liang Y, Connelly MA. Qi J, et al. J Lipid Res. 2010 Dec;51(12):3559-67. doi: 10.1194/jlr.D008029. Epub 2010 Aug 28. J Lipid Res. 2010. PMID: 20805092 Free PMC article.

6

Endothelial lipase is localized to follicular epithelial cells in the thyroid gland and is moderately expressed in adipocytes.

Connelly MA, D'Andrea MR, Qi J, Dzordzorme KC, Damiano BP. Connelly MA, et al. Among authors: qi j. J Histochem Cytochem. 2012 Sep;60(9):694-705. doi: 10.1369/0022155412454110. Epub 2012 Jun 26. J Histochem Cytochem. 2012. PMID: 22740344 Free PMC article.

7

Synthesis and biological evaluation of benzocyclobutane-C-glycosides as potent and orally active SGLT1/SGLT2 dual inhibitors.

Kuo GH, Gaul MD, Liang Y, Xu JZ, Du F, Hornby P, Xu G, Qi J, Wallace N, Lee S, Grant E, Murray WV, Demarest K. Kuo GH, et al. Among authors: qi j. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1182-1187. doi: 10.1016/j.bmcl.2018.02.057. Epub 2018 Mar 1. Bioorg Med Chem Lett. 2018. PMID: 29523385

8

6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB₁) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity.

Zhang YM, Greco MN, Macielag MJ, Teleha CA, DesJarlais RL, Tang Y, Ho G, Hou C, Chen C, Zhao S, Kauffman J, Camacho R, Qi J, Murray W, Demarest K, Leonard J. Zhang YM, et al. Among authors: qi j. J Med Chem. 2018 Nov 21;61(22):10276-10298. doi: 10.1021/acs.jmedchem.8b01467. Epub 2018 Oct 31. J Med Chem. 2018. PMID: 30339387

9

Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.

Xu G, Gaul MD, Liu Z, DesJarlais RL, Qi J, Wang W, Krosky D, Petrounia I, Milligan CM, Hermans A, Lu HR, Huang DZ, Xu JZ, Spurlino JC. Xu G, et al. Among authors: qi j. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127602. doi: 10.1016/j.bmcl.2020.127602. Epub 2020 Oct 7. Bioorg Med Chem Lett. 2020. PMID: 33038544

10

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

Qi J, Lang W, Geisler JG, Wang P, Petrounia I, Mai S, Smith C, Askari H, Struble GT, Williams R, Bhanot S, Monia BP, Bayoumy S, Grant E, Caldwell GW, Todd MJ, Liang Y, Gaul MD, Demarest KT, Connelly MA. Qi J, et al. J Lipid Res. 2012 Jun;53(6):1106-16. doi: 10.1194/jlr.M020156. Epub 2012 Apr 3. J Lipid Res. 2012. PMID: 22493088 Free PMC article.

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