Vacca JP - Search Results

1

8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.

Fisher TE, Kim B, Staas DD, Lyle TA, Young SD, Vacca JP, Zrada MM, Hazuda DJ, Felock PJ, Schleif WA, Gabryelski LJ, Anari MR, Kochansky CJ, Wai JS. Fisher TE, et al. Among authors: vacca jp. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6511-5. doi: 10.1016/j.bmcl.2007.09.086. Epub 2007 Sep 29. Bioorg Med Chem Lett. 2007. PMID: 17931865

2

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

deSolms SJ, Giuliani EA, Guare JP, Vacca JP, Sanders WM, Graham SL, Wiggins JM, Darke PL, Sigal IS, Zugay JA, et al. deSolms SJ, et al. Among authors: vacca jp. J Med Chem. 1991 Sep;34(9):2852-7. doi: 10.1021/jm00113a025. J Med Chem. 1991. PMID: 1910089

3

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

Vacca JP, Guare JP, deSolms SJ, Sanders WM, Giuliani EA, Young SD, Darke PL, Zugay J, Sigal IS, Schleif WA, et al. Vacca JP, et al. J Med Chem. 1991 Mar;34(3):1225-8. doi: 10.1021/jm00107a050. J Med Chem. 1991. PMID: 2002465 No abstract available.

4

Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors.

Huff JR, Baldwin JJ, deSolms SJ, Guare JP Jr, Hunt CA, Randall WC, Sanders WS, Smith SJ, Vacca JP, Zrada MM. Huff JR, et al. Among authors: vacca jp. J Med Chem. 1988 Mar;31(3):641-5. doi: 10.1021/jm00398a025. J Med Chem. 1988. PMID: 2831365

5

Metabolism of synthetic inositol trisphosphate analogs.

Polokoff MA, Bencen GH, Vacca JP, deSolms SJ, Young SD, Huff JR. Polokoff MA, et al. Among authors: vacca jp. J Biol Chem. 1988 Aug 25;263(24):11922-7. J Biol Chem. 1988. PMID: 2841338 Free article.

6

Synthesis, antiviral activity, and bioavailability studies of gamma-lactam derived HIV protease inhibitors.

Hungate RW, Chen JL, Starbuck KE, Vacca JP, McDaniel SL, Levin RB, Dorsey BD, Guare JP, Holloway MK, Whitter W, et al. Hungate RW, et al. Among authors: vacca jp. Bioorg Med Chem. 1994 Sep;2(9):859-79. doi: 10.1016/s0968-0896(00)82037-4. Bioorg Med Chem. 1994. PMID: 7712123

7

A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site.

Holloway MK, Wai JM, Halgren TA, Fitzgerald PM, Vacca JP, Dorsey BD, Levin RB, Thompson WJ, Chen LJ, deSolms SJ. Holloway MK, et al. Among authors: vacca jp. J Med Chem. 1995 Jan 20;38(2):305-17. doi: 10.1021/jm00002a012. J Med Chem. 1995. PMID: 7830273

8

L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.

Dorsey BD, Levin RB, McDaniel SL, Vacca JP, Guare JP, Darke PL, Zugay JA, Emini EA, Schleif WA, Quintero JC, et al. Dorsey BD, et al. Among authors: vacca jp. J Med Chem. 1994 Oct 14;37(21):3443-51. doi: 10.1021/jm00047a001. J Med Chem. 1994. PMID: 7932573

9

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Vacca JP, Dorsey BD, Schleif WA, Levin RB, McDaniel SL, Darke PL, Zugay J, Quintero JC, Blahy OM, Roth E, et al. Vacca JP, et al. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4096-100. doi: 10.1073/pnas.91.9.4096. Proc Natl Acad Sci U S A. 1994. PMID: 8171040 Free PMC article.

10

Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.

Tucker TJ, Lumma WC, Lewis SD, Gardell SJ, Lucas BJ, Baskin EP, Woltmann R, Lynch JJ, Lyle EA, Appleby SD, Chen IW, Dancheck KB, Vacca JP. Tucker TJ, et al. Among authors: vacca jp. J Med Chem. 1997 May 23;40(11):1565-9. doi: 10.1021/jm970140s. J Med Chem. 1997. PMID: 9171866

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