Junnotula V - Search Results

1

Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.

Solano B, Junnotula V, Marín A, Villar R, Burguete A, Vicente E, Pérez-Silanes S, Aldana I, Monge A, Dutta S, Sarkar U, Gates KS. Solano B, et al. Among authors: junnotula v. J Med Chem. 2007 Nov 1;50(22):5485-92. doi: 10.1021/jm0703993. Epub 2007 Oct 2. J Med Chem. 2007. PMID: 17910426

2

DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.

Junnotula V, Rajapakse A, Arbillaga L, de Cerain AL, Solano B, Villar R, Monge A, Gates KS. Junnotula V, et al. Bioorg Med Chem. 2010 May 1;18(9):3125-32. doi: 10.1016/j.bmc.2010.03.042. Epub 2010 Mar 19. Bioorg Med Chem. 2010. PMID: 20371184 Free PMC article.

3

Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.

Junnotula V, Sarkar U, Sinha S, Gates KS. Junnotula V, et al. J Am Chem Soc. 2009 Jan 28;131(3):1015-24. doi: 10.1021/ja8049645. J Am Chem Soc. 2009. PMID: 19117394 Free PMC article.

4

Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.

Shen X, Rajapakse A, Gallazzi F, Junnotula V, Fuchs-Knotts T, Glaser R, Gates KS. Shen X, et al. Among authors: junnotula v. Chem Res Toxicol. 2014 Jan 21;27(1):111-8. doi: 10.1021/tx400356y. Epub 2013 Dec 19. Chem Res Toxicol. 2014. PMID: 24328261 Free PMC article.

5

DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).

Chowdhury G, Junnotula V, Daniels JS, Greenberg MM, Gates KS. Chowdhury G, et al. Among authors: junnotula v. J Am Chem Soc. 2007 Oct 24;129(42):12870-7. doi: 10.1021/ja074432m. Epub 2007 Sep 27. J Am Chem Soc. 2007. PMID: 17900117 Free PMC article.

6

N-Nitrosodimethylamine investigations in Muta™Mouse define point-of-departure values and demonstrate less-than-additive somatic mutant frequency accumulations.

Lynch AM, Howe J, Hildebrand D, Harvey JS, Burman M, Harte DSG, Chen L, Kmett C, Shi W, McHugh CF, Patel KK, Junnotula V, Kenny J, Haworth R, Wills JW. Lynch AM, et al. Among authors: junnotula v. Mutagenesis. 2024 Mar 12;39(2):96-118. doi: 10.1093/mutage/geae001. Mutagenesis. 2024. PMID: 38183622 Free PMC article.

7

LC-MS/MS quantification of asymmetric dimethyl arginine and symmetric dimethyl arginine in plasma using surrogate matrix and derivatization with fluorescamine.

Junnotula V, Jones BR, Gorman S, Shen M, Mulvana D. Junnotula V, et al. Bioanalysis. 2020 Nov;12(22):1607-1619. doi: 10.4155/bio-2020-0223. Epub 2020 Nov 5. Bioanalysis. 2020. PMID: 33151745

8

Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study.

Perez HL, Junnotula V, Knecht D, Nie H, Sanchez Y, Boehm JC, Booth-Genthe C, Yan H, Davis R, Callahan JF. Perez HL, et al. Among authors: junnotula v. Analyst. 2014 Apr 21;139(8):1902-12. doi: 10.1039/c3an02216a. Analyst. 2014. PMID: 24563904

9

Development and validation of a simple and sensitive method for quantification of levodopa and carbidopa in rat and monkey plasma using derivatization and UPLC-MS/MS.

Junnotula V, Licea-Perez H. Junnotula V, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:47-53. doi: 10.1016/j.jchromb.2013.03.004. Epub 2013 Mar 14. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23548675

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