Gates KS - Search Results

1

Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues.

Solano B, Junnotula V, Marín A, Villar R, Burguete A, Vicente E, Pérez-Silanes S, Aldana I, Monge A, Dutta S, Sarkar U, Gates KS. Solano B, et al. Among authors: gates ks. J Med Chem. 2007 Nov 1;50(22):5485-92. doi: 10.1021/jm0703993. Epub 2007 Oct 2. J Med Chem. 2007. PMID: 17910426

2

DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.

Junnotula V, Rajapakse A, Arbillaga L, de Cerain AL, Solano B, Villar R, Monge A, Gates KS. Junnotula V, et al. Among authors: gates ks. Bioorg Med Chem. 2010 May 1;18(9):3125-32. doi: 10.1016/j.bmc.2010.03.042. Epub 2010 Mar 19. Bioorg Med Chem. 2010. PMID: 20371184 Free PMC article.

3

Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.

Junnotula V, Sarkar U, Sinha S, Gates KS. Junnotula V, et al. Among authors: gates ks. J Am Chem Soc. 2009 Jan 28;131(3):1015-24. doi: 10.1021/ja8049645. J Am Chem Soc. 2009. PMID: 19117394 Free PMC article.

4

Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.

Shen X, Rajapakse A, Gallazzi F, Junnotula V, Fuchs-Knotts T, Glaser R, Gates KS. Shen X, et al. Among authors: gates ks. Chem Res Toxicol. 2014 Jan 21;27(1):111-8. doi: 10.1021/tx400356y. Epub 2013 Dec 19. Chem Res Toxicol. 2014. PMID: 24328261 Free PMC article.

5

DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions.

Chowdhury G, Sarkar U, Pullen S, Wilson WR, Rajapakse A, Fuchs-Knotts T, Gates KS. Chowdhury G, et al. Among authors: gates ks. Chem Res Toxicol. 2012 Jan 13;25(1):197-206. doi: 10.1021/tx2004213. Epub 2011 Nov 22. Chem Res Toxicol. 2012. PMID: 22084973

6

Synthesis, Crystal Structure, and Rotational Energy Profile of 3-Cyclopropyl-1,2,4-benzotriazine 1,4-Di-N-oxide.

Sarkar U, Glaser R, Parsons ZD, Barnes CL, Gates KS. Sarkar U, et al. Among authors: gates ks. J Chem Crystallogr. 2010 Jul;40(7):624-629. doi: 10.1007/s10870-010-9707-9. J Chem Crystallogr. 2010. PMID: 22294856 Free PMC article.

7

Exploiting the Inherent Photophysical Properties of the Major Tirapazamine Metabolite in the Development of Profluorescent Substrates for Enzymes That Catalyze the Bioreductive Activation of Hypoxia-Selective Anticancer Prodrugs.

Shen X, Laber CH, Sarkar U, Galazzi F, Johnson KM, Mahieu NG, Hillebrand R, Fuchs-Knotts T, Barnes CL, Baker GA, Gates KS. Shen X, et al. Among authors: gates ks. J Org Chem. 2018 Mar 16;83(6):3126-3131. doi: 10.1021/acs.joc.7b03035. Epub 2018 Feb 26. J Org Chem. 2018. PMID: 29461834

8

Electronic structures and spin topologies of gamma-picoliniumyl radicals. A study of the homolysis of N-methyl-gamma-picolinium and of benzo-, dibenzo-, and naphthoannulated analogs.

Glaser R, Sui Y, Sarkar U, Gates KS. Glaser R, et al. Among authors: gates ks. J Phys Chem A. 2008 May 29;112(21):4800-14. doi: 10.1021/jp8011987. J Phys Chem A. 2008. PMID: 18494451 Free PMC article.

9

DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).

Chowdhury G, Junnotula V, Daniels JS, Greenberg MM, Gates KS. Chowdhury G, et al. Among authors: gates ks. J Am Chem Soc. 2007 Oct 24;129(42):12870-7. doi: 10.1021/ja074432m. Epub 2007 Sep 27. J Am Chem Soc. 2007. PMID: 17900117 Free PMC article.

10

Interstrand cross-links generated by abasic sites in duplex DNA.

Dutta S, Chowdhury G, Gates KS. Dutta S, et al. Among authors: gates ks. J Am Chem Soc. 2007 Feb 21;129(7):1852-3. doi: 10.1021/ja067294u. Epub 2007 Jan 25. J Am Chem Soc. 2007. PMID: 17253689 Free PMC article. No abstract available.

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