Wolfrum C - Search Results

1

Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

Wolfrum C, Shi S, Jayaprakash KN, Jayaraman M, Wang G, Pandey RK, Rajeev KG, Nakayama T, Charrise K, Ndungo EM, Zimmermann T, Koteliansky V, Manoharan M, Stoffel M. Wolfrum C, et al. Nat Biotechnol. 2007 Oct;25(10):1149-57. doi: 10.1038/nbt1339. Epub 2007 Sep 16. Nat Biotechnol. 2007. PMID: 17873866

2

Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.

Wolfrum C, Besser D, Luca E, Stoffel M. Wolfrum C, et al. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11624-9. doi: 10.1073/pnas.1931483100. Epub 2003 Sep 19. Proc Natl Acad Sci U S A. 2003. PMID: 14500912 Free PMC article.

3

Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.

Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M. Wolfrum C, et al. Nature. 2004 Dec 23;432(7020):1027-32. doi: 10.1038/nature03047. Nature. 2004. PMID: 15616563

4

Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis.

Wolfrum C, Poy MN, Stoffel M. Wolfrum C, et al. Nat Med. 2005 Apr;11(4):418-22. doi: 10.1038/nm1211. Epub 2005 Mar 27. Nat Med. 2005. PMID: 15793583

5

Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion.

Wolfrum C, Stoffel M. Wolfrum C, et al. Cell Metab. 2006 Feb;3(2):99-110. doi: 10.1016/j.cmet.2006.01.001. Cell Metab. 2006. PMID: 16459311 Free article.

6

Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M.

Wolfrum C, Howell JJ, Ndungo E, Stoffel M. Wolfrum C, et al. J Biol Chem. 2008 Jun 13;283(24):16940-9. doi: 10.1074/jbc.M801930200. Epub 2008 Apr 1. J Biol Chem. 2008. PMID: 18381283 Free article.

7

Regulation of adaptive behaviour during fasting by hypothalamic Foxa2.

Silva JP, von Meyenn F, Howell J, Thorens B, Wolfrum C, Stoffel M. Silva JP, et al. Among authors: wolfrum c. Nature. 2009 Dec 3;462(7273):646-50. doi: 10.1038/nature08589. Nature. 2009. PMID: 19956259

8

Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles.

Nakayama T, Butler JS, Sehgal A, Severgnini M, Racie T, Sharman J, Ding F, Morskaya SS, Brodsky J, Tchangov L, Kosovrasti V, Meys M, Nechev L, Wang G, Peng CG, Fang Y, Maier M, Rajeev KG, Li R, Hettinger J, Barros S, Clausen V, Zhang X, Wang Q, Hutabarat R, Dokholyan NV, Wolfrum C, Manoharan M, Kotelianski V, Stoffel M, Sah DW. Nakayama T, et al. Among authors: wolfrum c. Mol Ther. 2012 Aug;20(8):1582-9. doi: 10.1038/mt.2012.33. Epub 2012 Jun 5. Mol Ther. 2012. PMID: 22850721 Free PMC article.

9

High-Throughput Single-Cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma.

Liu Q, Ge W, Wang T, Lan J, Martínez-Jarquín S, Wolfrum C, Stoffel M, Zenobi R. Liu Q, et al. Among authors: wolfrum c. Angew Chem Int Ed Engl. 2021 Nov 8;60(46):24534-24542. doi: 10.1002/anie.202107223. Epub 2021 Oct 11. Angew Chem Int Ed Engl. 2021. PMID: 34505339 Free PMC article.

10

Decreased glibenclamide uptake in hepatocytes of hepatocyte nuclear factor-1alpha-deficient mice: a mechanism for hypersensitivity to sulfonylurea therapy in patients with maturity-onset diabetes of the young, type 3 (MODY3).

Boileau P, Wolfrum C, Shih DQ, Yang TA, Wolkoff AW, Stoffel M. Boileau P, et al. Among authors: wolfrum c. Diabetes. 2002 Dec;51 Suppl 3:S343-8. doi: 10.2337/diabetes.51.2007.s343. Diabetes. 2002. PMID: 12475773

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