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Page 1
Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists.
McDonald IM, Austin C, Buck IM, Dunstone DJ, Gaffen J, Griffin E, Harper EA, Hull RA, Kalindjian SB, Linney ID, Low CM, Patel D, Pether MJ, Raynor M, Roberts SP, Shaxted ME, Spencer J, Steel KI, Sykes DA, Wright PT, Xun W. McDonald IM, et al. Among authors: pether mj. J Med Chem. 2007 Oct 4;50(20):4789-92. doi: 10.1021/jm0707626. Epub 2007 Sep 12. J Med Chem. 2007. PMID: 17850061
Scaffold hopping with molecular field points: identification of a cholecystokinin-2 (CCK2) receptor pharmacophore and its use in the design of a prototypical series of pyrrole- and imidazole-based CCK2 antagonists.
Low CM, Buck IM, Cooke T, Cushnir JR, Kalindjian SB, Kotecha A, Pether MJ, Shankley NP, Vinter JG, Wright L. Low CM, et al. Among authors: pether mj. J Med Chem. 2005 Nov 3;48(22):6790-802. doi: 10.1021/jm049069y. J Med Chem. 2005. PMID: 16250638
Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.
Buck IM, Black JW, Cooke T, Dunstone DJ, Gaffen JD, Griffin EP, Harper EA, Hull RA, Kalindjian SB, Lilley EJ, Linney ID, Low CM, McDonald IM, Pether MJ, Roberts SP, Shankley NP, Shaxted ME, Steel KI, Sykes DA, Tozer MJ, Watt GF, Walker MK, Wright L, Wright PT. Buck IM, et al. Among authors: pether mj. J Med Chem. 2005 Nov 3;48(22):6803-12. doi: 10.1021/jm0490686. J Med Chem. 2005. PMID: 16250639
Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion.
McDonald IM, Black JW, Buck IM, Dunstone DJ, Griffin EP, Harper EA, Hull RA, Kalindjian SB, Lilley EJ, Linney ID, Pether MJ, Roberts SP, Shaxted ME, Spencer J, Steel KI, Sykes DA, Walker MK, Watt GF, Wright L, Wright PT, Xun W. McDonald IM, et al. Among authors: pether mj. J Med Chem. 2007 Jun 28;50(13):3101-12. doi: 10.1021/jm070139l. Epub 2007 May 31. J Med Chem. 2007. PMID: 17536796
16 results