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Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.
O'Neill HC, Laverty DC, Patzlaff NE, Cohen BN, Fonck C, McKinney S, McIntosh JM, Lindstrom JM, Lester HA, Grady SR, Marks MJ. O'Neill HC, et al. Among authors: laverty dc. Pharmacol Biochem Behav. 2013 Jan;103(3):603-21. doi: 10.1016/j.pbb.2012.10.014. Epub 2012 Nov 1. Pharmacol Biochem Behav. 2013. PMID: 23123803 Free PMC article.