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Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.
Leshchiner ES, Rush JS, Durney MA, Cao Z, Dančík V, Chittick B, Wu H, Petrone A, Bittker JA, Phillips A, Perez JR, Shamji AF, Kaushik VK, Daly MJ, Graham DB, Schreiber SL, Xavier RJ. Leshchiner ES, et al. Among authors: chittick b. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11392-11397. doi: 10.1073/pnas.1705748114. Epub 2017 Oct 9. Proc Natl Acad Sci U S A. 2017. PMID: 29073062 Free PMC article.