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Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.
Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, Abu-Asab MS, Borojerdi J, Warfel NA, Gardner ER, Danish M, Hollander MC, Kawabata S, Tsokos M, Figg WD, Steeg PS, Dennis PA. Gills JJ, et al. Among authors: gardner er. Clin Cancer Res. 2007 Sep 1;13(17):5183-94. doi: 10.1158/1078-0432.CCR-07-0161. Clin Cancer Res. 2007. PMID: 17785575
A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors.
Blumenthal GM, Gills JJ, Ballas MS, Bernstein WB, Komiya T, Dechowdhury R, Morrow B, Root H, Chun G, Helsabeck C, Steinberg SM, LoPiccolo J, Kawabata S, Gardner ER, Figg WD, Dennis PA. Blumenthal GM, et al. Among authors: gardner er. Oncotarget. 2014 Sep 30;5(18):8161-72. doi: 10.18632/oncotarget.2415. Oncotarget. 2014. PMID: 25327558 Free PMC article. Clinical Trial.
Selective leukemic-cell killing by a novel functional class of thalidomide analogs.
Ge Y, Montano I, Rustici G, Freebern WJ, Haggerty CM, Cui W, Ponciano-Jackson D, Chandramouli GV, Gardner ER, Figg WD, Abu-Asab M, Tsokos M, Jackson SH, Gardner K. Ge Y, et al. Among authors: gardner er, gardner k. Blood. 2006 Dec 15;108(13):4126-35. doi: 10.1182/blood-2006-04-017046. Epub 2006 Aug 29. Blood. 2006. PMID: 16940421 Free PMC article.
Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies.
Kummar S, Gutierrez M, Gardner ER, Donovan E, Hwang K, Chung EJ, Lee MJ, Maynard K, Kalnitskiy M, Chen A, Melillo G, Ryan QC, Conley B, Figg WD, Trepel JB, Zwiebel J, Doroshow JH, Murgo AJ. Kummar S, et al. Among authors: gardner er. Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5411-7. doi: 10.1158/1078-0432.CCR-07-0791. Clin Cancer Res. 2007. PMID: 17875771 Clinical Trial.
Thalidomide analogues as anticancer drugs.
Aragon-Ching JB, Li H, Gardner ER, Figg WD. Aragon-Ching JB, et al. Among authors: gardner er. Recent Pat Anticancer Drug Discov. 2007 Jun;2(2):167-74. doi: 10.2174/157489207780832478. Recent Pat Anticancer Drug Discov. 2007. PMID: 17975653 Free PMC article. Review.
A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer.
Kelly RJ, Draper D, Chen CC, Robey RW, Figg WD, Piekarz RL, Chen X, Gardner ER, Balis FM, Venkatesan AM, Steinberg SM, Fojo T, Bates SE. Kelly RJ, et al. Among authors: gardner er. Clin Cancer Res. 2011 Feb 1;17(3):569-80. doi: 10.1158/1078-0432.CCR-10-1725. Epub 2010 Nov 16. Clin Cancer Res. 2011. PMID: 21081657 Free PMC article. Clinical Trial.
68 results