Dennis PA - Search Results

1

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.

Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, Abu-Asab MS, Borojerdi J, Warfel NA, Gardner ER, Danish M, Hollander MC, Kawabata S, Tsokos M, Figg WD, Steeg PS, Dennis PA. Gills JJ, et al. Among authors: dennis pa. Clin Cancer Res. 2007 Sep 1;13(17):5183-94. doi: 10.1158/1078-0432.CCR-07-0161. Clin Cancer Res. 2007. PMID: 17785575

2

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

Brognard J, Clark AS, Ni Y, Dennis PA. Brognard J, et al. Among authors: dennis pa. Cancer Res. 2001 May 15;61(10):3986-97. Cancer Res. 2001. PMID: 11358816

3

Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.

Cuello M, Ettenberg SA, Clark AS, Keane MM, Posner RH, Nau MM, Dennis PA, Lipkowitz S. Cuello M, et al. Among authors: dennis pa. Cancer Res. 2001 Jun 15;61(12):4892-900. Cancer Res. 2001. PMID: 11406568

4

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

Clark AS, West K, Streicher S, Dennis PA. Clark AS, et al. Among authors: dennis pa. Mol Cancer Ther. 2002 Jul;1(9):707-17. Mol Cancer Ther. 2002. PMID: 12479367

5

Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.

Clark AS, West KA, Blumberg PM, Dennis PA. Clark AS, et al. Among authors: dennis pa. Cancer Res. 2003 Feb 15;63(4):780-6. Cancer Res. 2003. PMID: 12591726

6

Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.

Bianco R, Shin I, Ritter CA, Yakes FM, Basso A, Rosen N, Tsurutani J, Dennis PA, Mills GB, Arteaga CL. Bianco R, et al. Among authors: dennis pa. Oncogene. 2003 May 8;22(18):2812-22. doi: 10.1038/sj.onc.1206388. Oncogene. 2003. PMID: 12743604

7

Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo.

West KA, Linnoila IR, Belinsky SA, Harris CC, Dennis PA. West KA, et al. Among authors: dennis pa. Cancer Res. 2004 Jan 15;64(2):446-51. doi: 10.1158/0008-5472.can-03-3241. Cancer Res. 2004. PMID: 14744754

8

Targeting aberrant signal transduction pathways in lung cancer.

Gills JJ, Granville CA, Dennis PA. Gills JJ, et al. Among authors: dennis pa. Cancer Biol Ther. 2004 Feb;3(2):147-55. doi: 10.4161/cbt.3.2.612. Epub 2004 Feb 1. Cancer Biol Ther. 2004. PMID: 14764993 Free article. Review.

9

Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.

Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP, Dennis PA. Castillo SS, et al. Among authors: dennis pa. Cancer Res. 2004 Apr 15;64(8):2782-92. doi: 10.1158/0008-5472.can-03-1530. Cancer Res. 2004. PMID: 15087394

10

The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.

Gills JJ, Dennis PA. Gills JJ, et al. Among authors: dennis pa. Expert Opin Investig Drugs. 2004 Jul;13(7):787-97. doi: 10.1517/13543784.13.7.787. Expert Opin Investig Drugs. 2004. PMID: 15212619 Review.

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