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Page 1
Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.
Zhong W, Liu H, Kaller MR, Henley C, Magal E, Nguyen T, Osslund TD, Powers D, Rzasa RM, Wang HL, Wang W, Xiong X, Zhang J, Norman MH. Zhong W, et al. Among authors: henley c. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5384-9. doi: 10.1016/j.bmcl.2007.07.045. Epub 2007 Aug 6. Bioorg Med Chem Lett. 2007. PMID: 17709247
Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.
Kaller MR, Zhong W, Henley C, Magal E, Nguyen T, Powers D, Rzasa RM, Wang W, Xiong X, Norman MH. Kaller MR, et al. Among authors: henley c. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6591-4. doi: 10.1016/j.bmcl.2009.10.027. Epub 2009 Oct 13. Bioorg Med Chem Lett. 2009. PMID: 19864130
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade.
Gavva NR, Bannon AW, Hovland DN Jr, Lehto SG, Klionsky L, Surapaneni S, Immke DC, Henley C, Arik L, Bak A, Davis J, Ernst N, Hever G, Kuang R, Shi L, Tamir R, Wang J, Wang W, Zajic G, Zhu D, Norman MH, Louis JC, Magal E, Treanor JJ. Gavva NR, et al. Among authors: henley c. J Pharmacol Exp Ther. 2007 Oct;323(1):128-37. doi: 10.1124/jpet.107.125674. Epub 2007 Jul 25. J Pharmacol Exp Ther. 2007. PMID: 17652633
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core.
Harrington PE, St Jean DJ Jr, Clarine J, Coulter TS, Croghan M, Davenport A, Davis J, Ghiron C, Hutchinson J, Kelly MG, Lott F, Lu JY, Martin D, Morony S, Poon SF, Portero-Larragueta E, Reagan JD, Regal KA, Tasker A, Wang M, Yang Y, Yao G, Zeng Q, Henley C 3rd, Fotsch C. Harrington PE, et al. Among authors: henley c 3rd. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5544-7. doi: 10.1016/j.bmcl.2010.07.060. Epub 2010 Aug 12. Bioorg Med Chem Lett. 2010. PMID: 20708930
Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism.
Wehn PM, Harrington PE, Carlson TJ, Davis J, Deprez P, Fotsch CH, Grillo MP, Lu JY, Morony S, Pattabiraman K, Poon SF, Reagan JD, St Jean DJ Jr, Temal T, Wang M, Yang Y, Henley C 3rd, Lively SE. Wehn PM, et al. Among authors: henley c 3rd. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6625-8. doi: 10.1016/j.bmcl.2013.10.050. Epub 2013 Oct 31. Bioorg Med Chem Lett. 2013. PMID: 24215889
Calcification inhibitors and Wnt signaling proteins are implicated in bovine artery smooth muscle cell calcification in the presence of phosphate and vitamin D sterols.
Shalhoub V, Shatzen E, Henley C, Boedigheimer M, McNinch J, Manoukian R, Damore M, Fitzpatrick D, Haas K, Twomey B, Kiaei P, Ward S, Lacey DL, Martin D. Shalhoub V, et al. Among authors: henley c. Calcif Tissue Int. 2006 Dec;79(6):431-42. doi: 10.1007/s00223-006-0126-z. Epub 2006 Dec 8. Calcif Tissue Int. 2006. PMID: 17171500
FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality.
Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, Bi V, Renshaw L, Hawkins N, Wang W, Chen C, Tsai MM, Cattley RC, Wronski TJ, Xia X, Li X, Henley C, Eschenberg M, Richards WG. Shalhoub V, et al. Among authors: henley c. J Clin Invest. 2012 Jul;122(7):2543-53. doi: 10.1172/JCI61405. Epub 2012 Jun 25. J Clin Invest. 2012. PMID: 22728934 Free PMC article.
194 results