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Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Wilson DP, Wan ZK, Xu WX, Kirincich SJ, Follows BC, Joseph-McCarthy D, Foreman K, Moretto A, Wu J, Zhu M, Binnun E, Zhang YL, Tam M, Erbe DV, Tobin J, Xu X, Leung L, Shilling A, Tam SY, Mansour TS, Lee J. Wilson DP, et al. Among authors: tobin j. J Med Chem. 2007 Sep 20;50(19):4681-98. doi: 10.1021/jm0702478. Epub 2007 Aug 17. J Med Chem. 2007. PMID: 17705360
Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.
Xiang J, Wan ZK, Li HQ, Ipek M, Binnun E, Nunez J, Chen L, McKew JC, Mansour TS, Xu X, Suri V, Tam M, Xing Y, Li X, Hahm S, Tobin J, Saiah E. Xiang J, et al. Among authors: tobin j. J Med Chem. 2008 Jul 24;51(14):4068-71. doi: 10.1021/jm8004948. Epub 2008 Jun 26. J Med Chem. 2008. PMID: 18578516
Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.
Wan ZK, Lee J, Hotchandani R, Moretto A, Binnun E, Wilson DP, Kirincich SJ, Follows BC, Ipek M, Xu W, Joseph-McCarthy D, Zhang YL, Tam M, Erbe DV, Tobin JF, Li W, Tam SY, Mansour TS, Wu J. Wan ZK, et al. Among authors: tobin jf. ChemMedChem. 2008 Oct;3(10):1525-9. doi: 10.1002/cmdc.200800188. ChemMedChem. 2008. PMID: 18798205 No abstract available.
1,032 results