Zahn G - Search Results

1

The role of integrin alpha5beta1 in the regulation of corneal neovascularization.

Muether PS, Dell S, Kociok N, Zahn G, Stragies R, Vossmeyer D, Joussen AM. Muether PS, et al. Among authors: zahn g. Exp Eye Res. 2007 Sep;85(3):356-65. doi: 10.1016/j.exer.2007.06.004. Epub 2007 Jun 15. Exp Eye Res. 2007. PMID: 17659277

2

Modulation of hypoxia-induced neovascularization by JSM6427, an integrin alpha5beta1 inhibiting molecule.

Maier AK, Kociok N, Zahn G, Vossmeyer D, Stragies R, Muether PS, Joussen AM. Maier AK, et al. Among authors: zahn g. Curr Eye Res. 2007 Sep;32(9):801-12. doi: 10.1080/02713680701553052. Curr Eye Res. 2007. PMID: 17882713

3

Suppression and regression of choroidal neovascularization by systemic administration of an alpha5beta1 integrin antagonist.

Umeda N, Kachi S, Akiyama H, Zahn G, Vossmeyer D, Stragies R, Campochiaro PA. Umeda N, et al. Among authors: zahn g. Mol Pharmacol. 2006 Jun;69(6):1820-8. doi: 10.1124/mol.105.020941. Epub 2006 Mar 9. Mol Pharmacol. 2006. PMID: 16527907

4

Design and synthesis of a new class of selective integrin alpha5beta1 antagonists.

Stragies R, Osterkamp F, Zischinsky G, Vossmeyer D, Kalkhof H, Reimer U, Zahn G. Stragies R, et al. Among authors: zahn g. J Med Chem. 2007 Aug 9;50(16):3786-94. doi: 10.1021/jm070002v. Epub 2007 Jul 6. J Med Chem. 2007. PMID: 17616113

5

An alpha5beta1 integrin inhibitor attenuates glioma growth.

Färber K, Synowitz M, Zahn G, Vossmeyer D, Stragies R, van Rooijen N, Kettenmann H. Färber K, et al. Among authors: zahn g. Mol Cell Neurosci. 2008 Dec;39(4):579-85. doi: 10.1016/j.mcn.2008.08.005. Epub 2008 Sep 4. Mol Cell Neurosci. 2008. PMID: 18804537

6

Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization.

Zahn G, Vossmeyer D, Stragies R, Wills M, Wong CG, Löffler KU, Adamis AP, Knolle J. Zahn G, et al. Arch Ophthalmol. 2009 Oct;127(10):1329-35. doi: 10.1001/archophthalmol.2009.265. Arch Ophthalmol. 2009. PMID: 19822850

7

Discovery of orally available integrin alpha5beta1 antagonists.

Zischinsky G, Osterkamp F, Vossmeyer D, Zahn G, Scharn D, Zwintscher A, Stragies R. Zischinsky G, et al. Among authors: zahn g. Bioorg Med Chem Lett. 2010 Jan 1;20(1):380-2. doi: 10.1016/j.bmcl.2009.10.073. Epub 2009 Oct 28. Bioorg Med Chem Lett. 2010. PMID: 19910191

8

SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists.

Zischinsky G, Osterkamp F, Vossmeyer D, Zahn G, Scharn D, Zwintscher A, Stragies R. Zischinsky G, et al. Among authors: zahn g. Bioorg Med Chem Lett. 2010 Jan 1;20(1):65-8. doi: 10.1016/j.bmcl.2009.11.030. Epub 2009 Nov 14. Bioorg Med Chem Lett. 2010. PMID: 19959360

9

Probing integrin selectivity: rational design of highly active and selective ligands for the alpha5beta1 and alphavbeta3 integrin receptor.

Heckmann D, Meyer A, Marinelli L, Zahn G, Stragies R, Kessler H. Heckmann D, et al. Among authors: zahn g. Angew Chem Int Ed Engl. 2007;46(19):3571-4. doi: 10.1002/anie.200700008. Angew Chem Int Ed Engl. 2007. PMID: 17394271 No abstract available.

10

Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade.

Dietrich T, Onderka J, Bock F, Kruse FE, Vossmeyer D, Stragies R, Zahn G, Cursiefen C. Dietrich T, et al. Among authors: zahn g. Am J Pathol. 2007 Jul;171(1):361-72. doi: 10.2353/ajpath.2007.060896. Am J Pathol. 2007. PMID: 17591980 Free PMC article.

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