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Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects.
He YL, Ligueros-Saylan M, Sunkara G, Sabo R, Zhao C, Wang Y, Campestrini J, Pommier F, Dole K, Marion A, Dole WP, Howard D. He YL, et al. Among authors: sunkara g. J Clin Pharmacol. 2008 Jan;48(1):85-95. doi: 10.1177/0091270007307880. Epub 2007 Nov 6. J Clin Pharmacol. 2008. PMID: 17986525 Clinical Trial.
Population pharmacokinetic modeling and noncompartmental analysis demonstrated bioequivalence between metformin component of metformin/vildagliptin fixed-dose combination products and metformin immediate-release tablet sourced from various countries.
Chitnis SD, Han Y, Yamaguchi M, Mita S, Zhao R, Sunkara G, Kulmatycki K. Chitnis SD, et al. Among authors: sunkara g. Clin Pharmacol Drug Dev. 2016 Jan;5(1):40-51. doi: 10.1002/cpdd.191. Epub 2015 May 15. Clin Pharmacol Drug Dev. 2016. PMID: 27119577
67 results