Lin YC - Search Results

1

Conformational flexibility in the flap domains of ligand-free HIV protease.

Heaslet H, Rosenfeld R, Giffin M, Lin YC, Tam K, Torbett BE, Elder JH, McRee DE, Stout CD. Heaslet H, et al. Among authors: lin yc. Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):866-75. doi: 10.1107/S0907444907029125. Epub 2007 Jul 17. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17642513

2

Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.

Lin YC, Perryman AL, Olson AJ, Torbett BE, Elder JH, Stout CD. Lin YC, et al. Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):540-8. doi: 10.1107/S0907444911011681. Epub 2011 May 12. Acta Crystallogr D Biol Crystallogr. 2011. PMID: 21636894 Free PMC article.

3

Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3.

Heaslet H, Kutilek V, Morris GM, Lin YC, Elder JH, Torbett BE, Stout CD. Heaslet H, et al. Among authors: lin yc. J Mol Biol. 2006 Mar 3;356(4):967-81. doi: 10.1016/j.jmb.2005.11.094. Epub 2005 Dec 20. J Mol Biol. 2006. PMID: 16403521

4

Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.

Heaslet H, Lin YC, Tam K, Torbett BE, Elder JH, Stout CD. Heaslet H, et al. Among authors: lin yc. Retrovirology. 2007 Jan 9;4:1. doi: 10.1186/1742-4690-4-1. Retrovirology. 2007. PMID: 17212810 Free PMC article.

5

A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant.

Giffin MJ, Heaslet H, Brik A, Lin YC, Cauvi G, Wong CH, McRee DE, Elder JH, Stout CD, Torbett BE. Giffin MJ, et al. Among authors: lin yc. J Med Chem. 2008 Oct 23;51(20):6263-70. doi: 10.1021/jm800149m. Epub 2008 Sep 30. J Med Chem. 2008. PMID: 18823110 Free PMC article.

6

Small molecule regulation of protein conformation by binding in the Flap of HIV protease.

Tiefenbrunn T, Forli S, Baksh MM, Chang MW, Happer M, Lin YC, Perryman AL, Rhee JK, Torbett BE, Olson AJ, Elder JH, Finn MG, Stout CD. Tiefenbrunn T, et al. Among authors: lin yc. ACS Chem Biol. 2013;8(6):1223-31. doi: 10.1021/cb300611p. Epub 2013 Mar 29. ACS Chem Biol. 2013. PMID: 23540839 Free PMC article.

7

Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries.

Chang MW, Giffin MJ, Muller R, Savage J, Lin YC, Hong S, Jin W, Whitby LR, Elder JH, Boger DL, Torbett BE. Chang MW, et al. Among authors: lin yc. Biochem J. 2010 Aug 1;429(3):527-32. doi: 10.1042/BJ20091645. Biochem J. 2010. PMID: 20507280 Free PMC article.

8

A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitors.

Brik A, Lin YC, Elder J, Wong CH. Brik A, et al. Among authors: lin yc. Chem Biol. 2002 Aug;9(8):891-6. doi: 10.1016/s1074-5521(02)00184-9. Chem Biol. 2002. PMID: 12204688

9

Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases.

Lin YC, Beck Z, Morris GM, Olson AJ, Elder JH. Lin YC, et al. J Virol. 2003 Jun;77(12):6589-600. doi: 10.1128/jvi.77.12.6589-6600.2003. J Virol. 2003. PMID: 12767979 Free PMC article.

10

Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors.

Brik A, Muldoon J, Lin YC, Elder JH, Goodsell DS, Olson AJ, Fokin VV, Sharpless KB, Wong CH. Brik A, et al. Among authors: lin yc. Chembiochem. 2003 Nov 7;4(11):1246-8. doi: 10.1002/cbic.200300724. Chembiochem. 2003. PMID: 14613121 No abstract available.

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