Heaslet H - Search Results

1

Conformational flexibility in the flap domains of ligand-free HIV protease.

Heaslet H, Rosenfeld R, Giffin M, Lin YC, Tam K, Torbett BE, Elder JH, McRee DE, Stout CD. Heaslet H, et al. Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):866-75. doi: 10.1107/S0907444907029125. Epub 2007 Jul 17. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17642513

2

Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3.

Heaslet H, Kutilek V, Morris GM, Lin YC, Elder JH, Torbett BE, Stout CD. Heaslet H, et al. J Mol Biol. 2006 Mar 3;356(4):967-81. doi: 10.1016/j.jmb.2005.11.094. Epub 2005 Dec 20. J Mol Biol. 2006. PMID: 16403521

3

A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant.

Giffin MJ, Heaslet H, Brik A, Lin YC, Cauvi G, Wong CH, McRee DE, Elder JH, Stout CD, Torbett BE. Giffin MJ, et al. Among authors: heaslet h. J Med Chem. 2008 Oct 23;51(20):6263-70. doi: 10.1021/jm800149m. Epub 2008 Sep 30. J Med Chem. 2008. PMID: 18823110 Free PMC article.

4

Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.

Heaslet H, Lin YC, Tam K, Torbett BE, Elder JH, Stout CD. Heaslet H, et al. Retrovirology. 2007 Jan 9;4:1. doi: 10.1186/1742-4690-4-1. Retrovirology. 2007. PMID: 17212810 Free PMC article.

5

Crystalline ligand transitions in lamprey hemoglobin. Structural evidence for the regulation of oxygen affinity.

Heaslet HA, Royer WE Jr. Heaslet HA, et al. J Biol Chem. 2001 Jul 13;276(28):26230-6. doi: 10.1074/jbc.M101391200. Epub 2001 May 4. J Biol Chem. 2001. PMID: 11340069 Free article.

6

The 2.7 A crystal structure of deoxygenated hemoglobin from the sea lamprey (Petromyzon marinus): structural basis for a lowered oxygen affinity and Bohr effect.

Heaslet HA, Royer WE Jr. Heaslet HA, et al. Structure. 1999 May;7(5):517-26. doi: 10.1016/s0969-2126(99)80068-9. Structure. 1999. PMID: 10378271 Free article.

7

Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus.

Evdokimov AG, Mekel M, Hutchings K, Narasimhan L, Holler T, McGrath T, Beattie B, Fauman E, Yan C, Heaslet H, Walter R, Finzel B, Ohren J, McConnell P, Braden T, Sun F, Spessard C, Banotai C, Al-Kassim L, Ma W, Wengender P, Kole D, Garceau N, Toogood P, Liu J. Evdokimov AG, et al. Among authors: heaslet h. J Struct Biol. 2008 Apr;162(1):152-69. doi: 10.1016/j.jsb.2007.11.002. Epub 2007 Nov 13. J Struct Biol. 2008. PMID: 18086534

8

Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim.

Heaslet H, Harris M, Fahnoe K, Sarver R, Putz H, Chang J, Subramanyam C, Barreiro G, Miller JR. Heaslet H, et al. Proteins. 2009 Aug 15;76(3):706-17. doi: 10.1002/prot.22383. Proteins. 2009. PMID: 19280600

9

Cooperative hemoglobins: conserved fold, diverse quaternary assemblies and allosteric mechanisms.

Royer WE Jr, Knapp JE, Strand K, Heaslet HA. Royer WE Jr, et al. Among authors: heaslet ha. Trends Biochem Sci. 2001 May;26(5):297-304. doi: 10.1016/s0968-0004(01)01811-4. Trends Biochem Sci. 2001. PMID: 11343922 Review.

10

Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin.

Heaslet H, Shaw B, Mistry A, Miller AA. Heaslet H, et al. J Struct Biol. 2009 Aug;167(2):129-35. doi: 10.1016/j.jsb.2009.04.010. Epub 2009 May 3. J Struct Biol. 2009. PMID: 19416756

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