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Page 1
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.
Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L, Cupitt J, Paterson I, Thompson RB, Chow K, O'Regan DP, Zhao L, Wharton J, Kiely DG, Kinnaird A, Boukouris AE, White C, Nagendran J, Freed DH, Wort SJ, Gibbs JSR, Wilkins MR. Michelakis ED, et al. Sci Transl Med. 2017 Oct 25;9(413):eaao4583. doi: 10.1126/scitranslmed.aao4583. Sci Transl Med. 2017. PMID: 29070699 Free article. Clinical Trial.
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED. Nagendran J, et al. Among authors: michelakis ed. Circulation. 2007 Jul 17;116(3):238-48. doi: 10.1161/CIRCULATIONAHA.106.655266. Epub 2007 Jul 2. Circulation. 2007. PMID: 17606845
CD36 expression contributes to age-induced cardiomyopathy in mice.
Koonen DP, Febbraio M, Bonnet S, Nagendran J, Young ME, Michelakis ED, Dyck JR. Koonen DP, et al. Among authors: michelakis ed. Circulation. 2007 Nov 6;116(19):2139-47. doi: 10.1161/CIRCULATIONAHA.107.712901. Epub 2007 Oct 22. Circulation. 2007. PMID: 17967771
Myocardial Functional Decline During Prolonged Ex Situ Heart Perfusion.
Hatami S, White CW, Shan S, Haromy A, Qi X, Ondrus M, Kinnear A, Himmat S, Michelakis E, Nagendran J, Freed DH. Hatami S, et al. Among authors: michelakis e. Ann Thorac Surg. 2019 Aug;108(2):499-507. doi: 10.1016/j.athoracsur.2019.01.076. Epub 2019 Mar 12. Ann Thorac Surg. 2019. PMID: 30872100
174 results