Ashton K - Search Results

1

Total synthesis of (-)-reidispongiolide A, an actin-targeting marine macrolide.

Paterson I, Ashton K, Britton R, Cecere G, Chouraqui G, Florence GJ, Stafford J. Paterson I, et al. Among authors: ashton k. Angew Chem Int Ed Engl. 2007;46(32):6167-71. doi: 10.1002/anie.200702178. Angew Chem Int Ed Engl. 2007. PMID: 17615611 No abstract available.

2

Toward the synthesis of reidispongiolide a: stereocontrolled synthesis of the C17-C22 and C23-C35 degradation fragments.

Paterson I, Ashton K, Britton R, Knust H. Paterson I, et al. Among authors: ashton k. Org Lett. 2003 May 29;5(11):1963-6. doi: 10.1021/ol034558y. Org Lett. 2003. PMID: 12762697

3

Synthesis of antimicrofilament marine macrolides: synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A.

Paterson I, Britton R, Ashton K, Knust H, Stafford J. Paterson I, et al. Among authors: ashton k. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):11986-91. doi: 10.1073/pnas.0401548101. Epub 2004 Jun 16. Proc Natl Acad Sci U S A. 2004. PMID: 15201432 Free PMC article.

4

Total synthesis of (-)-reidispongiolide A, an actin-targeting macrolide isolated from the marine sponge Reidispongia coerulea.

Paterson I, Ashton K, Britton R, Cecere G, Chouraqui G, Florence GJ, Knust H, Stafford J. Paterson I, et al. Among authors: ashton k. Chem Asian J. 2008 Feb 1;3(2):367-87. doi: 10.1002/asia.200700357. Chem Asian J. 2008. PMID: 18181126

5

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.

St Jean DJ Jr, Ashton KS, Bartberger MD, Chen J, Chmait S, Cupples R, Galbreath E, Helmering J, Hong FT, Jordan SR, Liu L, Kunz RK, Michelsen K, Nishimura N, Pennington LD, Poon SF, Reid D, Sivits G, Stec MM, Tadesse S, Tamayo N, Van G, Yang KC, Zhang J, Norman MH, Fotsch C, Lloyd DJ, Hale C. St Jean DJ Jr, et al. Among authors: ashton ks. J Med Chem. 2014 Jan 23;57(2):325-38. doi: 10.1021/jm4016747. Epub 2014 Jan 9. J Med Chem. 2014. PMID: 24405213

6

Nonracemic synthesis of GK-GKRP disruptor AMG-3969.

Bourbeau MP, Ashton KS, Yan J, St Jean DJ Jr. Bourbeau MP, et al. J Org Chem. 2014 Apr 18;79(8):3684-7. doi: 10.1021/jo500336e. Epub 2014 Apr 10. J Org Chem. 2014. PMID: 24678849

7

Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors.

Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, Chen JJ, Chen N, Frohn MJ, Goodman G, Kopecky DJ, Liu L, Lopez P, Low JD, Ma V, Minatti AE, Nguyen TT, Nishimura N, Pickrell AJ, Reed AB, Shin Y, Siegmund AC, Tamayo NA, Tegley CM, Walton MC, Wang HL, Wurz RP, Xue M, Yang KC, Achanta P, Bartberger MD, Canon J, Hollis LS, McCarter JD, Mohr C, Rex K, Saiki AY, San Miguel T, Volak LP, Wang KH, Whittington DA, Zech SG, Lipford JR, Cee VJ. Lanman BA, et al. Among authors: ashton ks. J Med Chem. 2020 Jan 9;63(1):52-65. doi: 10.1021/acs.jmedchem.9b01180. Epub 2019 Dec 24. J Med Chem. 2020. PMID: 31820981

8

A new series of potent benzodiazepine gamma-secretase inhibitors.

Churcher I, Ashton K, Butcher JW, Clarke EE, Harrison T, Lewis HD, Owens AP, Teall MR, Williams S, Wrigley JD. Churcher I, et al. Among authors: ashton k. Bioorg Med Chem Lett. 2003 Jan 20;13(2):179-83. doi: 10.1016/s0960-894x(02)00909-5. Bioorg Med Chem Lett. 2003. PMID: 12482419

9

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.

Nishimura N, Norman MH, Liu L, Yang KC, Ashton KS, Bartberger MD, Chmait S, Chen J, Cupples R, Fotsch C, Helmering J, Jordan SR, Kunz RK, Pennington LD, Poon SF, Siegmund A, Sivits G, Lloyd DJ, Hale C, St Jean DJ Jr. Nishimura N, et al. Among authors: ashton ks. J Med Chem. 2014 Apr 10;57(7):3094-116. doi: 10.1021/jm5000497. Epub 2014 Mar 31. J Med Chem. 2014. PMID: 24611879

10

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.

Hong FT, Norman MH, Ashton KS, Bartberger MD, Chen J, Chmait S, Cupples R, Fotsch C, Jordan SR, Lloyd DJ, Sivits G, Tadesse S, Hale C, St Jean DJ Jr. Hong FT, et al. J Med Chem. 2014 Jul 24;57(14):5949-64. doi: 10.1021/jm5001979. Epub 2014 Jul 8. J Med Chem. 2014. PMID: 25001129

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