Buynak JD - Search Results

1

Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.

Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR. Helfand MS, et al. Among authors: buynak jd. Biochemistry. 2007 Jul 24;46(29):8689-99. doi: 10.1021/bi700581q. Epub 2007 Jun 27. Biochemistry. 2007. PMID: 17595114

2

Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence.

Totir MA, Cha J, Ishiwata A, Wang B, Sheri A, Anderson VE, Buynak J, Mobashery S, Carey PR. Totir MA, et al. Biochemistry. 2008 Apr 1;47(13):4094-101. doi: 10.1021/bi702348w. Epub 2008 Mar 7. Biochemistry. 2008. PMID: 18324783

3

Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.

Sampson JM, Ke W, Bethel CR, Pagadala SR, Nottingham MD, Bonomo RA, Buynak JD, van den Akker F. Sampson JM, et al. Among authors: buynak jd. Antimicrob Agents Chemother. 2011 May;55(5):2303-9. doi: 10.1128/AAC.01360-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357298 Free PMC article.

4

The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants.

Ke W, Rodkey EA, Sampson JM, Skalweit MJ, Sheri A, Pagadala SR, Nottingham MD, Buynak JD, Bonomo RA, van den Akker F. Ke W, et al. Among authors: buynak jd. ChemMedChem. 2012 Jun;7(6):1002-8. doi: 10.1002/cmdc.201200006. Epub 2012 Mar 21. ChemMedChem. 2012. PMID: 22438274 Free PMC article.

5

Carboxylation and decarboxylation of active site Lys 84 controls the activity of OXA-24 β-lactamase of Acinetobacter baumannii: Raman crystallographic and solution evidence.

Che T, Bonomo RA, Shanmugam S, Bethel CR, Pusztai-Carey M, Buynak JD, Carey PR. Che T, et al. Among authors: buynak jd. J Am Chem Soc. 2012 Jul 11;134(27):11206-15. doi: 10.1021/ja303168n. Epub 2012 Jun 28. J Am Chem Soc. 2012. PMID: 22702961 Free PMC article.

6

Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation.

Ke W, Pattanaik P, Bethel CR, Sheri A, Buynak JD, Bonomo RA, van den Akker F. Ke W, et al. Among authors: buynak jd. PLoS One. 2012;7(11):e49035. doi: 10.1371/journal.pone.0049035. Epub 2012 Nov 8. PLoS One. 2012. PMID: 23145056 Free PMC article.

7

Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.

Rodkey EA, Winkler ML, Bethel CR, Pagadala SR, Buynak JD, Bonomo RA, van den Akker F. Rodkey EA, et al. Among authors: buynak jd. PLoS One. 2014 Jan 16;9(1):e85892. doi: 10.1371/journal.pone.0085892. eCollection 2014. PLoS One. 2014. PMID: 24454944 Free PMC article.

8

Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone.

Che T, Rodkey EA, Bethel CR, Shanmugam S, Ding Z, Pusztai-Carey M, Nottingham M, Chai W, Buynak JD, Bonomo RA, van den Akker F, Carey PR. Che T, et al. Among authors: buynak jd. Biochemistry. 2015 Jan 27;54(3):734-43. doi: 10.1021/bi501197t. Epub 2015 Jan 8. Biochemistry. 2015. PMID: 25536850 Free PMC article.

9

Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.

Sulton D, Pagan-Rodriguez D, Zhou X, Liu Y, Hujer AM, Bethel CR, Helfand MS, Thomson JM, Anderson VE, Buynak JD, Ng LM, Bonomo RA. Sulton D, et al. Among authors: buynak jd. J Biol Chem. 2005 Oct 21;280(42):35528-36. doi: 10.1074/jbc.M501251200. Epub 2005 Jun 29. J Biol Chem. 2005. PMID: 15987690 Free article.

10

Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfone.

Padayatti PS, Sheri A, Totir MA, Helfand MS, Carey MP, Anderson VE, Carey PR, Bethel CR, Bonomo RA, Buynak JD, van den Akker F. Padayatti PS, et al. Among authors: buynak jd. J Am Chem Soc. 2006 Oct 11;128(40):13235-42. doi: 10.1021/ja063715w. J Am Chem Soc. 2006. PMID: 17017804 Free PMC article.

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