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An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells.
Knies D, Klobuch S, Xue SA, Birtel M, Echchannaoui H, Yildiz O, Omokoko T, Guillaume P, Romero P, Stauss H, Sahin U, Herr W, Theobald M, Thomas S, Voss RH. Knies D, et al. Among authors: voss rh. Oncotarget. 2016 Apr 19;7(16):21199-221. doi: 10.18632/oncotarget.8385. Oncotarget. 2016. PMID: 27028870 Free PMC article.
Enhancing the expression and function of an EBV-TCR on engineered T cells by combining Sc-TCR design with CRISPR editing to prevent mispairing.
Xue SA, Chen Y, Voss RH, Kisan V, Wang B, Chen KK, He FQ, Cheng XX, Scolamiero L, Holler A, Gao L, Morris E, Stauss HJ. Xue SA, et al. Among authors: voss rh. Cell Mol Immunol. 2020 Dec;17(12):1275-1277. doi: 10.1038/s41423-020-0396-9. Epub 2020 Mar 17. Cell Mol Immunol. 2020. PMID: 32203185 Free PMC article. No abstract available.
Designing TCR for cancer immunotherapy.
Voss RH, Kuball J, Theobald M. Voss RH, et al. Methods Mol Med. 2005;109:229-56. doi: 10.1385/1-59259-862-5:229. Methods Mol Med. 2005. PMID: 15585925
34 results