Fukumoto H - Search Results

1

Expression of APP pathway mRNAs and proteins in Alzheimer's disease.

Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT. Matsui T, et al. Among authors: fukumoto h. Brain Res. 2007 Aug 3;1161:116-23. doi: 10.1016/j.brainres.2007.05.050. Epub 2007 Jun 5. Brain Res. 2007. PMID: 17586478

2

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.

Fukumoto H, Cheung BS, Hyman BT, Irizarry MC. Fukumoto H, et al. Arch Neurol. 2002 Sep;59(9):1381-9. doi: 10.1001/archneur.59.9.1381. Arch Neurol. 2002. PMID: 12223024

3

Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.

Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. Matsui T, et al. Among authors: fukumoto h. J Neuropathol Exp Neurol. 2006 May;65(5):508-15. doi: 10.1097/01.jnen.0000229238.05748.12. J Neuropathol Exp Neurol. 2006. PMID: 16772874

4

Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain.

Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC. Ingelsson M, et al. Among authors: fukumoto h. Neurology. 2004 Mar 23;62(6):925-31. doi: 10.1212/01.wnl.0000115115.98960.37. Neurology. 2004. PMID: 15037694

5

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.

Kinoshita A, Fukumoto H, Shah T, Whelan CM, Irizarry MC, Hyman BT. Kinoshita A, et al. Among authors: fukumoto h. J Cell Sci. 2003 Aug 15;116(Pt 16):3339-46. doi: 10.1242/jcs.00643. Epub 2003 Jun 26. J Cell Sci. 2003. PMID: 12829747

6

Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.

Fukumoto H, Tennis M, Locascio JJ, Hyman BT, Growdon JH, Irizarry MC. Fukumoto H, et al. Arch Neurol. 2003 Jul;60(7):958-64. doi: 10.1001/archneur.60.7.958. Arch Neurol. 2003. PMID: 12873852

7

APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis.

Fukumoto H, Ingelsson M, Gårevik N, Wahlund LO, Nukina N, Yaguchi Y, Shibata M, Hyman BT, Rebeck GW, Irizarry MC. Fukumoto H, et al. Exp Neurol. 2003 Sep;183(1):249-53. doi: 10.1016/s0014-4886(03)00088-8. Exp Neurol. 2003. PMID: 12957508

8

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT. Lleó A, et al. Among authors: fukumoto h. J Biol Chem. 2003 Nov 28;278(48):47370-5. doi: 10.1074/jbc.M308480200. Epub 2003 Sep 5. J Biol Chem. 2003. PMID: 12960155 Free article.

9

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

Fukumoto H, Rosene DL, Moss MB, Raju S, Hyman BT, Irizarry MC. Fukumoto H, et al. Am J Pathol. 2004 Feb;164(2):719-25. doi: 10.1016/s0002-9440(10)63159-8. Am J Pathol. 2004. PMID: 14742275 Free PMC article.

10

Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.

Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT, Ingelsson M. Lee J, et al. Among authors: fukumoto h. Exp Neurol. 2005 Jul;194(1):91-6. doi: 10.1016/j.expneurol.2005.01.026. Exp Neurol. 2005. PMID: 15899246

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