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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC. Weng AP, et al. Among authors: pear ws. Genes Dev. 2006 Aug 1;20(15):2096-109. doi: 10.1101/gad.1450406. Epub 2006 Jul 17. Genes Dev. 2006. PMID: 16847353 Free PMC article.
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
Wouters BJ, Jordà MA, Keeshan K, Louwers I, Erpelinck-Verschueren CA, Tielemans D, Langerak AW, He Y, Yashiro-Ohtani Y, Zhang P, Hetherington CJ, Verhaak RG, Valk PJ, Löwenberg B, Tenen DG, Pear WS, Delwel R. Wouters BJ, et al. Among authors: pear ws. Blood. 2007 Nov 15;110(10):3706-14. doi: 10.1182/blood-2007-02-073486. Epub 2007 Aug 1. Blood. 2007. PMID: 17671232 Free PMC article.
Notch regulation of early thymocyte development.
Yashiro-Ohtani Y, Ohtani T, Pear WS. Yashiro-Ohtani Y, et al. Among authors: pear ws. Semin Immunol. 2010 Oct;22(5):261-9. doi: 10.1016/j.smim.2010.04.015. Epub 2010 Jul 13. Semin Immunol. 2010. PMID: 20630772 Review.
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.
Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS. Yashiro-Ohtani Y, et al. Among authors: pear ws. Genes Dev. 2009 Jul 15;23(14):1665-76. doi: 10.1101/gad.1793709. Genes Dev. 2009. PMID: 19605688 Free PMC article.
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.
Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS. Yashiro-Ohtani Y, et al. Among authors: pear ws. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4946-53. doi: 10.1073/pnas.1407079111. Epub 2014 Nov 4. Proc Natl Acad Sci U S A. 2014. PMID: 25369933 Free PMC article.
172 results